plasminogen Antibody (G-7): sc-376405
- plasminogen Antibody (G-7) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 16-105 of plasminogen of human origin
- Anti-plasminogen Antibody (G-7) is recommended for detection of plasminogen of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-plasminogen Antibody (G-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for plasminogen Antibody (G-7) for WB applications. These reagents are now offered in bundles with plasminogen Antibody (G-7) (see ordering information below).
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Plasminogen Antibody (G-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects plasminogen from mouse, rat, and human sources through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Plasminogen (G-7) antibody is available non-conjugated or conjugated to agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® variants. Plasminogen plays a crucial role in the fibrinolytic system, converting to plasmin to break down fibrin in blood clots. This conversion maintains hemostasis and prevents excessive clot formation that could lead to thrombosis. Plasminogen′s structure includes a 561-amino acid heavy chain and 230-amino acid light chain, both essential for enzymatic activity and protein interactions in the fibrinolytic cascade. The heavy chain contains the catalytic domain for plasmin′s proteolytic activity, while the light chain regulates plasminogen activation. Understanding plasminogen′s structure and conversion to plasmin helps develop therapeutic strategies for modulating fibrinolysis in cardiovascular diseases and cancer.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
plasminogen Antibody (G-7) References:
- Regulation of plasminogen binding to neutrophils. | Herren, T., et al. 2001. Blood. 97: 1070-8. PMID: 11159539
- The functions of plasminogen in cardiovascular disease. | Plow, EF. and Hoover-Plow, J. 2004. Trends Cardiovasc Med. 14: 180-6. PMID: 15261889
- Effects of N-terminal peptide of Glu-plasminogen on the activation of Glu-plasminogen and its conversion to Lys-plasminogen. | Urano, T., et al. 1991. Thromb Res. 61: 349-59. PMID: 1676546
- Plasminogen and tissue-type plasminogen activator bind to immobilized fibronectin. | Salonen, EM., et al. 1985. J Biol Chem. 260: 12302-7. PMID: 2413022
- Plasminogen Activator Inhibitor-1 Protects Mice Against Cardiac Fibrosis by Inhibiting Urokinase-type Plasminogen Activator-mediated Plasminogen Activation. | Gupta, KK., et al. 2017. Sci Rep. 7: 365. PMID: 28336948
- Interaction of heparin with plasminogen activators and plasminogen: effects on the activation of plasminogen. | Andrade-Gordon, P. and Strickland, S. 1986. Biochemistry. 25: 4033-40. PMID: 2943315
- Plasminogen and the Plasminogen Receptor, Plg-RKT, Regulate Macrophage Phenotypic, and Functional Changes. | Vago, JP., et al. 2019. Front Immunol. 10: 1458. PMID: 31316511
- Kringles of substrate plasminogen provide a 'catalytic switch' in plasminogen to plasmin turnover by Streptokinase. | Sharma, V., et al. 2020. Biochem J. 477: 953-970. PMID: 32069359
- Interaction of plasminogen activators and inhibitors with plasminogen and fibrin. | Lijnen, HR. and Collen, D. 1982. Semin Thromb Hemost. 8: 2-10. PMID: 6460318
- Plasminogen and plasminogen activators protect against renal injury in crescentic glomerulonephritis. | Kitching, AR., et al. 1997. J Exp Med. 185: 963-8. PMID: 9120402
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
plasminogen Antibody (G-7) | sc-376405 | 200 µg/ml | $322.00 | |||
plasminogen Antibody (G-7): m-IgG Fc BP-HRP Bundle | sc-529867 | 200 µg Ab; 10 µg BP | $361.00 | |||
plasminogen Antibody (G-7): m-IgGκ BP-HRP Bundle | sc-522944 | 200 µg Ab, 40 µg BP | $361.00 | |||
plasminogen Antibody (G-7): m-IgG1 BP-HRP Bundle | sc-543734 | 200 µg Ab; 20 µg BP | $361.00 | |||
plasminogen Antibody (G-7) AC | sc-376405 AC | 500 µg/ml, 25% agarose | $424.00 | |||
plasminogen Antibody (G-7) HRP | sc-376405 HRP | 200 µg/ml | $322.00 | |||
plasminogen Antibody (G-7) FITC | sc-376405 FITC | 200 µg/ml | $336.00 | |||
plasminogen Antibody (G-7) PE | sc-376405 PE | 200 µg/ml | $349.00 | |||
plasminogen Antibody (G-7) Alexa Fluor® 488 | sc-376405 AF488 | 200 µg/ml | $364.00 | |||
plasminogen Antibody (G-7) Alexa Fluor® 546 | sc-376405 AF546 | 200 µg/ml | $364.00 | |||
plasminogen Antibody (G-7) Alexa Fluor® 594 | sc-376405 AF594 | 200 µg/ml | $364.00 | |||
plasminogen Antibody (G-7) Alexa Fluor® 647 | sc-376405 AF647 | 200 µg/ml | $364.00 | |||
plasminogen Antibody (G-7) Alexa Fluor® 680 | sc-376405 AF680 | 200 µg/ml | $364.00 | |||
plasminogen Antibody (G-7) Alexa Fluor® 790 | sc-376405 AF790 | 200 µg/ml | $364.00 |