plasminogen Antibody (B-11): sc-376324

Plasminogen Antibody (B-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects plasminogen protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-plasminogen antibody (B-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Plasminogen plays a crucial role in the fibrinolytic system, where plasminogen is converted into plasmin, a serine protease essential for the breakdown of fibrin in blood clots. This process is vital for maintaining hemostasis and preventing excessive clot formation, which can lead to thrombosis. Plasminogen (B-11) antibody enables research on plasminogen, which is synthesized in the liver and circulates in the bloodstream, where tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA) activate plasminogen. The structure of plasminogen consists of a heavy chain and a light chain, which are critical for enzymatic activity and interaction with various substrates. Understanding plasminogen structure informs the design of therapeutic agents aimed at modulating activity in pathological conditions such as cardiovascular diseases and cancer. Plasminogen monoclonal antibody (B-11) helps researchers effectively study the dynamics of plasminogen activation and implications in health and disease.

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plasminogen Antibody (B-11) References:

1. The plasminogen activation system in tumor growth, invasion, and metastasis.  |  Andreasen, PA., et al. 2000. Cell Mol Life Sci. 57: 25-40. PMID: 10949579
2. Angiostatin generation by cathepsin D secreted by human prostate carcinoma cells.  |  Morikawa, W., et al. 2000. J Biol Chem. 275: 38912-20. PMID: 10986284
3. Plasminogen activators in inflammation and sepsis.  |  Pechlaner, Ch. 2002. Acta Med Austriaca. 29: 80-8. PMID: 12168568
4. Characterization of the gene for human plasminogen, a key proenzyme in the fibrinolytic system.  |  Petersen, TE., et al. 1990. J Biol Chem. 265: 6104-11. PMID: 2318848
5. Activation of fibrin-bound plasminogen by pro-urokinase and its complementariness with that by tissue plasminogen activator.  |  Gurewich, V. 1988. Enzyme. 40: 97-108. PMID: 2971533
6. Molecular cloning and characterization of a full-length cDNA clone for human plasminogen.  |  Forsgren, M., et al. 1987. FEBS Lett. 213: 254-60. PMID: 3030813
7. Mechanisms of plasminogen activation by mammalian plasminogen activators.  |  Lijnen, HR. and Collen, D. 1988. Enzyme. 40: 90-6. PMID: 3139404
8. Breaking the fibrinolytic speed limit with microwheel co-delivery of tissue plasminogen activator and plasminogen.  |  Disharoon, D., et al. 2022. J Thromb Haemost. 20: 486-497. PMID: 34882946
9. The effects of variable glycosylation on the functional activities of ribonuclease, plasminogen and tissue plasminogen activator.  |  Rudd, PM., et al. 1995. Biochim Biophys Acta. 1248: 1-10. PMID: 7711052
10. Immunohistochemical localization of urokinase-type plasminogen activator, type-1 plasminogen-activator inhibitor, urokinase receptor and alpha(2)-macroglobulin receptor in human breast carcinomas.  |  Christensen, L., et al. 1996. Int J Cancer. 66: 441-52. PMID: 8635858
11. The mechanism of cancer-mediated conversion of plasminogen to the angiogenesis inhibitor angiostatin.  |  Gately, S., et al. 1997. Proc Natl Acad Sci U S A. 94: 10868-72. PMID: 9380726
12. Macrophage formation of angiostatin during inflammation. A byproduct of the activation of plasminogen.  |  Falcone, DJ., et al. 1998. J Biol Chem. 273: 31480-5. PMID: 9813061

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-plasminogen Antibody (B-11) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-plasminogen Antibody (B-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

plasminogen Antibody (B-11) Specifications

Alternate Product Name: Plasmin

Product Clone Name: B-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 123-155

Epitope Target: plasminogen

Epitope Species: human

Product Reactivity/Detection: plasminogen, plasmin heavy chain A, and the short form of plasmin heavy chain A

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for plasminogen Antibody (B-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin