plakophilin 3 Antibody (23E3/4): sc-59976

plakophilin 3 Antibody (23E3/4) is a mouse monoclonal IgG2b antibody that detects plakophilin 3 in mouse, rat, human, and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Plakophilin 3 is a 797 amino acid protein that belongs to the beta-catenin family and is characterized by eight arm-repeat domains, which are crucial for cell adhesion and signaling. Plakophilin 3 is primarily localized to desmosomes, specialized cell-cell junctions that provide mechanical strength to tissues, particularly in stratified epithelia that experience significant mechanical stress. Plakophilin 3 in desmosomes is vital for maintaining tissue integrity and facilitating communication between cells, which is essential for proper tissue function and response to stress. Plakophilin 3 has been implicated in lung carcinogenesis, where up-regulation serves as a significant marker for cancer progression, highlighting potential as a prognostic indicator and therapeutic target in lung cancer treatment. Through interactions with various proteins involved in desmosome formation and function, plakophilin 3 plays a critical role in maintaining cellular architecture and influencing signaling pathways that govern cell behavior.

The preferred plakophilin 3 antibody is plakophilin 3 Antibody (E-10): sc-166655.