plakophilin 1 Antibody (3G250): sc-59880

Plakophilin 1 Antibody (3G250) is a mouse monoclonal IgG1 antibody that detects plakophilin 1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Plakophilin 1 is a crucial component of desmosomes, which are specialized cell-cell junctions that provide mechanical strength to tissues, particularly in stratified epithelia that experience significant mechanical stress. Plakophilin 1 plays a vital role in mediating increases in desmosomal protein content and facilitating desmosome assembly, which is essential for maintaining tissue integrity and proper cell migration. Additionally, plakophilin 1′s localization to the nucleus suggests roles beyond structural support, potentially influencing gene expression and cellular signaling pathways. Understanding plakophilin 1 function is important for elucidating contributions to tissue architecture and the pathophysiology of diseases characterized by desmosomal dysfunction, such as certain skin disorders and cardiomyopathies. Anti-plakophilin 1 antibody (3G250) is an invaluable tool for researchers investigating the dynamics of desmosomal adhesion and molecular mechanisms underlying cell-cell interactions.

The preferred plakophilin 1 antibody is plakophilin 1 Antibody (10B2): sc-33636.