PKR2 Antibody (H-4): sc-365696

PKR2 Antibody (H-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects PKR2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PKR2 (H-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PKR2, a member of the prokineticin receptor family, plays a crucial role in mediating the effects of its ligands, such as EG-VEGF and Prokineticin-2, which are vital for numerous physiological processes. PKR2 is predominantly expressed in the central nervous system and is essential for normal development of the olfactory bulb, highlighting PKR2′s importance in sensory processing and neurodevelopment. Upon ligand binding, PKR2 interacts with G proteins, leading to intracellular calcium mobilization and activation of the MAPK pathway, which are critical for various functions including neuronal survival and circadian rhythm regulation. Mutations in the gene encoding PKR2 have been linked to Kallmann syndrome type 3, a condition characterized by anosmia and hypogonadotropic hypogonadism, underscoring PKR2′s significance in both developmental and physiological contexts.

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PKR2 Antibody (H-4) References:

1. Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor.  |  Lin, DC., et al. 2002. J Biol Chem. 277: 19276-80. PMID: 11886876
2. Molecular cloning and characterization of prokineticin receptors.  |  Soga, T., et al. 2002. Biochim Biophys Acta. 1579: 173-9. PMID: 12427552
3. Expression and regulation of the prokineticins (endocrine gland-derived vascular endothelial growth factor and Bv8) and their receptors in the human endometrium across the menstrual cycle.  |  Battersby, S., et al. 2004. J Clin Endocrinol Metab. 89: 2463-9. PMID: 15126578
4. Identification and pharmacological characterization of prokineticin 2 beta as a selective ligand for prokineticin receptor 1.  |  Chen, J., et al. 2005. Mol Pharmacol. 67: 2070-6. PMID: 15772293
5. Biological activities of Bv8 analogues.  |  Negri, L., et al. 2005. Br J Pharmacol. 146: 625-32. PMID: 16113687
6. Expression and oxygen regulation of endocrine gland-derived vascular endothelial growth factor/prokineticin-1 and its receptors in human placenta during early pregnancy.  |  Hoffmann, P., et al. 2006. Endocrinology. 147: 1675-84. PMID: 16384869
7. Abnormal development of the olfactory bulb and reproductive system in mice lacking prokineticin receptor PKR2.  |  Matsumoto, S., et al. 2006. Proc Natl Acad Sci U S A. 103: 4140-5. PMID: 16537498
8. Kallmann syndrome: mutations in the genes encoding prokineticin-2 and prokineticin receptor-2.  |  Dodé, C., et al. 2006. PLoS Genet. 2: e175. PMID: 17054399
9. The prokineticin receptor-1 (GPR73) promotes cardiomyocyte survival and angiogenesis.  |  Urayama, K., et al. 2007. FASEB J. 21: 2980-93. PMID: 17442730

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PKR2 Antibody (H-4) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-PKR2 Antibody (H-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PKR2 Antibody (H-4) Specifications

Alternate Product Name: PKR2

Product Clone Name: H-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-49

Epitope Target: PKR2

Epitope Species: human

Product Reactivity/Detection: PKR2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for PKR2 Antibody (H-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin