PKAα/β/γ cat Antibody (B-4): sc-365615

PKAα/β/γ cat Antibody (B-4) is a mouse monoclonal IgG2b kappa light chain antibody, engineered to detect the catalytic subunits alpha, beta, and gamma of protein kinase A (PKA) in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PKAα/β/γ cat monoclonal antibody (B-4) is raised against a unique epitope spanning amino acids 226-320 near the C-terminus of the human PKAα catalytic subunit, ensuring precise and selective recognition of PKAα, PKAβ, and PKAγ isoforms. Protein kinase A is a critical cAMP-dependent enzyme that orchestrates a wide range of cellular functions, including regulation of cell proliferation, ion transport, metabolism, and gene transcription. By phosphorylating specific target proteins, PKA modulates key signaling pathways that are essential for maintaining cellular homeostasis and responding to external stimuli. The catalytic subunits of PKA become active upon binding of cyclic AMP to the regulatory subunits, leading to their dissociation and subsequent translocation to various cellular compartments where they execute phosphorylation of substrates involved in diverse biological processes. The proper functioning of PKA is vital for numerous physiological processes, and its dysregulation is associated with various diseases such as cancer, diabetes, and neurological disorders. By providing reliable detection of PKA catalytic subunits, anti-PKAα/β/γ cat antibody (B-4) enables researchers to investigate the dynamic roles of PKA in cellular signaling networks, facilitating a deeper understanding of its involvement in both normal cellular functions and pathological conditions. PKAα/β/γ cat (B-4) antibody serves as an essential tool for advancing biomedical research and the development of targeted therapeutic strategies.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PKAα/β/γ cat Antibody (B-4) has 22 citations in a variety of scientific publications.

Primary antibodies like Anti-PKAα/β/γ cat Antibody (B-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PKAα/β/γ cat Antibody (B-4) Specifications

Alternate Product Name: PRKACA, PRKACB, PRKACG

Product Clone Name: B-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 226-320

Epitope Target: PKAα cat

Epitope Species: human

Product Reactivity/Detection: PKAα cat, PKAβ cat and PKAγ cat

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 22 citations in various scientific publications

Available Conjugates/Forms for PKAα/β/γ cat Antibody (B-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred PKAα cat antibody is PKAα cat Antibody (A-2): sc-28315.