PKA Iα reg Antibody (20): sc-136231

PKA Iα reg Antibody (20) is a mouse monoclonal IgG1 antibody that detects PKA I alpha reg protein of mouse, rat, human, and canine origin by western blotting (WB) and immunoprecipitation (IP). Anti-PKA I alpha reg antibody (20) is available as the non-conjugated format. PKA I alpha reg protein plays a crucial role in cellular signaling by acting as a tissue-specific regulator that downregulates the expression of several liver genes, which is vital for maintaining metabolic homeostasis and preventing aberrant cell growth. This regulatory function is particularly important in liver health, as dysregulation can lead to conditions such as hepatocellular carcinoma. PKA I alpha reg protein′s ability to modulate gene expression in response to cyclic AMP (cAMP) signaling highlights its significance in various physiological processes, including proliferation and metabolism. Notably, functional null mutations in the gene encoding PKA I alpha reg are linked to Carney complex, an autosomal dominant syndrome characterized by multiple neoplasms, including cardiac myxomas and endocrine tumors, underscoring PKA I alpha reg protein′s importance in tumor suppression and overall cellular regulation.

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PKA Iα reg Antibody (20) References:

1. Genetic heterogeneity and spectrum of mutations of the PRKAR1A gene in patients with the carney complex.  |  Kirschner, LS., et al. 2000. Hum Mol Genet. 9: 3037-46. PMID: 11115848
2. Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit (PRKAR1A) in patients with the 'complex of spotty skin pigmentation, myxomas, endocrine overactivity, and schwannomas' (Carney complex).  |  Stratakis, CA. 2002. Ann N Y Acad Sci. 968: 3-21. PMID: 12119264
3. Infra-additivity of combined treatments with selective D1 and D2 receptor antagonists for inhibiting sucrose reinforcement.  |  Schneider, LH., et al. 1991. Brain Res. 550: 122-4. PMID: 1832327
4. PRKAR1A overexpression is associated with increased ECPKA autoantibody in liver fluke-associated cholangiocarcinoma: application for assessment of the risk group.  |  Loilome, W., et al. 2012. Tumour Biol. 33: 2289-98. PMID: 22922884
5. Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis--representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase.  |  Beebe, SJ., et al. 1990. Mol Endocrinol. 4: 465-75. PMID: 2342480
6. Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133.  |  Gonzalez, GA. and Montminy, MR. 1989. Cell. 59: 675-80. PMID: 2573431
7. A cDNA clone encoding human cAMP-dependent protein kinase catalytic subunit C alpha.  |  Maldonado, F. and Hanks, SK. 1988. Nucleic Acids Res. 16: 8189-90. PMID: 2843813
8. Attempting to Solve the Pigmented Epithelioid Melanocytoma (PEM) Conundrum: PRKAR1A Inactivation Can Occur in Different Genetic Backgrounds (Common, Blue, and Spitz Subgroups) With Variation in Their Clinicopathologic Characteristics.  |  de la Fouchardiere, A., et al. 2022. Am J Surg Pathol. 46: 1106-1115. PMID: 35319526
9. PRKAR1A and SDCBP Serve as Potential Predictors of Heart Failure Following Acute Myocardial Infarction.  |  Chen, Q., et al. 2022. Front Immunol. 13: 878876. PMID: 35592331
10. Phosphorylation-dephosphorylation of enzymes.  |  Krebs, EG. and Beavo, JA. 1979. Annu Rev Biochem. 48: 923-59. PMID: 38740
11. Activation of protein kinase by physiological concentrations of cyclic AMP.  |  Beavo, JA., et al. 1974. Proc Natl Acad Sci U S A. 71: 3580-3. PMID: 4372627
12. Signal transduction through the cAMP-dependent protein kinase.  |  Meinkoth, JL., et al. 1993. Mol Cell Biochem. 127-128: 179-86. PMID: 7935349

The preferred PKA Iα/β reg antibody is PKA Iα/β reg Antibody (B-6): sc-271125.