PKA Iα/β reg Antibody (B-6): sc-271125

PKA Iα/β reg Antibody (B-6) is a mouse monoclonal IgG2b kappa light chain antibody that detects PKA I alpha / beta reg protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). PKA Iα/β reg (B-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PKA I alpha / beta regulatory protein plays a crucial role in cellular signaling pathways by modulating cAMP-dependent protein kinase (PKA) activity, which is essential for mediating diverse cellular responses to external stimuli such as growth, ion transport, and metabolic regulation. PKA Iα regulatory subunit, in particular, is known for tissue-specific functions, including downregulation of several liver genes, which is vital for maintaining metabolic homeostasis. Mutations in PKA Iα reg gene are linked to Carney complex, an autosomal dominant syndrome characterized by multiple neoplasms, including myxomas and endocrine tumors, highlighting PKA Iα reg importance in both normal physiology and disease states.

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PKA Iα/β reg Antibody (B-6) References:

1. Genetic heterogeneity and spectrum of mutations of the PRKAR1A gene in patients with the carney complex.  |  Kirschner, LS., et al. 2000. Hum Mol Genet. 9: 3037-46. PMID: 11115848
2. Infra-additivity of combined treatments with selective D1 and D2 receptor antagonists for inhibiting sucrose reinforcement.  |  Schneider, LH., et al. 1991. Brain Res. 550: 122-4. PMID: 1832327
3. Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis--representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase.  |  Beebe, SJ., et al. 1990. Mol Endocrinol. 4: 465-75. PMID: 2342480
4. PRKAR1B mutation associated with a new neurodegenerative disorder with unique pathology.  |  Wong, TH., et al. 2014. Brain. 137: 1361-73. PMID: 24722252
5. Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133.  |  Gonzalez, GA. and Montminy, MR. 1989. Cell. 59: 675-80. PMID: 2573431
6. A cDNA clone encoding human cAMP-dependent protein kinase catalytic subunit C alpha.  |  Maldonado, F. and Hanks, SK. 1988. Nucleic Acids Res. 16: 8189-90. PMID: 2843813
7. PRKAR1A deficiency impedes hypertrophy and reduces heart size.  |  Liu, Y., et al. 2020. Physiol Rep. 8: e14405. PMID: 32212257
8. Variants in PRKAR1B cause a neurodevelopmental disorder with autism spectrum disorder, apraxia, and insensitivity to pain.  |  Marbach, F., et al. 2021. Genet Med. 23: 1465-1473. PMID: 33833410
9. Phosphorylation-dephosphorylation of enzymes.  |  Krebs, EG. and Beavo, JA. 1979. Annu Rev Biochem. 48: 923-59. PMID: 38740
10. Activation of protein kinase by physiological concentrations of cyclic AMP.  |  Beavo, JA., et al. 1974. Proc Natl Acad Sci U S A. 71: 3580-3. PMID: 4372627
11. Signal transduction through the cAMP-dependent protein kinase.  |  Meinkoth, JL., et al. 1993. Mol Cell Biochem. 127-128: 179-86. PMID: 7935349
12. Transcription factors. CREB takes CBP to tango.  |  Nordheim, A. 1994. Nature. 370: 177-8. PMID: 8028657

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PKA Iα/β reg Antibody (B-6) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-PKA Iα/β reg Antibody (B-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PKA Iα/β reg Antibody (B-6) Specifications

Alternate Product Name: PKA Iα/β reg

Product Clone Name: B-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 246-335

Epitope Target: PKA Iα reg

Epitope Species: human

Product Reactivity/Detection: PKA Iα and PKA Iβ reg

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for PKA Iα/β reg Antibody (B-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin