PKA Iα/β reg Antibody (G-6): sc-271446
- PKA Iα/β reg Antibody (G-6) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 246-335 mapping within an internal region of PKA Iα reg of human origin
- recommended for detection of PKA Iα of mouse, rat and human origin, and PKC β reg of human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PKA Iα/β reg Antibody (G-6) for WB applications. These reagents are now offered in bundles with PKA Iα/β reg Antibody (G-6) (see ordering information below).
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PKA Iα/β reg Antibody (G-6) is a mouse monoclonal IgG1 antibody that detects PKA Iα/β reg in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PKA Iα/β reg plays a crucial role in cellular signaling by regulating the activity of the cAMP-dependent protein kinase (PKA), which is essential for mediating various physiological responses, including cell proliferation, metabolism, and gene expression. PKA Iα/β reg is primarily located in the cytoplasm and nucleus, where PKA Iα/β reg interacts with the PKA holoenzyme, facilitating the release of active catalytic subunits upon cAMP binding. This localization allows for precise control of PKA activity in response to extracellular signals, ensuring that cellular responses are appropriately modulated. Dysregulation of PKA Iα/β reg can lead to significant health issues, including the Carney complex, a genetic disorder characterized by multiple neoplasms and other systemic manifestations. PKA Iα/β reg Antibody (G-6) serves as an invaluable tool for researchers studying the intricate mechanisms of cAMP signaling and its implications in various diseases.
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PKA Iα/β reg Antibody (G-6) References:
- PRKAR1A is overexpressed and represents a possible therapeutic target in human cholangiocarcinoma. | Loilome, W., et al. 2011. Int J Cancer. 129: 34-44. PMID: 20824711
- The transcriptome that mediates increased cyclic adenosine monophosphate signaling in PRKAR1A defects and other settings. | Azevedo, MF. and Stratakis, CA. 2011. Endocr Pract. 17 Suppl 3: 2-7. PMID: 21454229
- Mutation frequency of PRKAR1B and the major familial dementia genes in a Dutch early onset dementia cohort. | Cohn-Hokke, PE., et al. 2014. J Neurol. 261: 2085-92. PMID: 25108559
- Identification of a novel mutation of the PRKAR1A gene in a patient with Carney complex with significant osteoporosis and recurrent fractures. | Papanastasiou, L., et al. 2016. Hormones (Athens). 15: 129-35. PMID: 27377598
- PRKAR1A is a functional tumor suppressor inhibiting ERK/Snail/E-cadherin pathway in lung adenocarcinoma. | Wang, S., et al. 2016. Sci Rep. 6: 39630. PMID: 27995993
- E2F3 promotes liver cancer progression under the regulation of circ-PRKAR1B. | Liu, G., et al. 2021. Mol Ther Nucleic Acids. 26: 104-113. PMID: 34513297
- EIF4A3-induced circular RNA PRKAR1B promotes osteosarcoma progression by miR-361-3p-mediated induction of FZD4 expression. | Feng, ZH., et al. 2021. Cell Death Dis. 12: 1025. PMID: 34716310
- Association between subclinical hyperthyroidism and a PRKAR1A gene variant in Carney complex patients: A case report and systematic review. | Wang, H., et al. 2022. Front Endocrinol (Lausanne). 13: 951133. PMID: 36213268
- Malignant melanotic nerve sheath tumor with PRKAR1A, KMT2C, and GNAQ mutations. | Terry, M., et al. 2022. Free Neuropathol. 3: PMID: 37284154
- Somatic Mutation of PRKAR1A in Four Cases of Sporadic Cardiac Myxoma. | Sun, Y., et al. 2023. Arch Iran Med. 26: 346-354. PMID: 38310436
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PKA Iα/β reg Antibody (G-6) | sc-271446 | 200 µg/ml | $322.00 | |||
PKA Iα/β reg Antibody (G-6): m-IgG Fc BP-HRP Bundle | sc-537635 | 200 µg Ab; 10 µg BP | $361.00 | |||
PKA Iα/β reg Antibody (G-6): m-IgGκ BP-HRP Bundle | sc-534965 | 200 µg Ab; 40 µg BP | $361.00 | |||
PKA Iα/β reg Antibody (G-6): m-IgG1 BP-HRP Bundle | sc-545272 | 200 µg Ab; 20 µg BP | $361.00 |