PITPβ Antibody (E-2): sc-515216

PITPβ Antibody (E-2) is a mouse monoclonal IgG3 antibody that detects PITPβ in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PITPβ is a crucial lipid binding protein that plays a significant role in the transport of phosphatidylinositol (PI) and phosphatidylcholine (PC) between cellular membranes, which is essential for the formation of second messenger molecules involved in critical signaling pathways, including phospholipase C and phosphoinositide 3-kinase pathways. PITPβ is predominantly located in the cytosol and is vital for the proper functioning of the Golgi apparatus, where PITPβ facilitates the mobilization of PI from the endoplasmic reticulum and regulates the release of PI from vesicles within the Golgi network. Notably, PITPβ exists in two isoforms due to alternative splicing, and while PITPβ is required for Golgi targeting, the constitutive phosphorylation of Ser 262 does not influence phospholipid transfer activity. The versatility of PITPβ in lipid transport underscores PITPβ′s importance in maintaining cellular signaling and membrane dynamics, making anti-PITPβ antibody (E-2) an invaluable tool for researchers studying lipid metabolism and cellular signaling pathways.

The preferred PITPβ antibody is PITPβ Antibody (G-3): sc-390500.