Pirh2 Antibody (C-12): sc-166293

Pirh2 Antibody (C-12) is a mouse monoclonal IgG1 antibody that detects Pirh2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Pirh2, also known as Androgen receptor N-terminal-interacting protein (ARNIP), ZN363, or CHIMP, plays a critical role in cellular regulation by functioning as a p53-induced ubiquitin-protein ligase, which promotes the degradation of the tumor suppressor protein p53. The interaction between Pirh2 and p53 is significant because p53 is a key regulator of the cell cycle and apoptosis, and Pirh2-mediated degradation can lead to oncogenic processes, contributing to malignant tumor development. The gene encoding Pirh2 is located on chromosome 4q21.1, and Pirh2 transcription is intricately regulated by p53 itself, creating a feedback loop that maintains cellular homeostasis. Notably, a decrease in Pirh2 expression results in elevated levels of p53, highlighting Pirh2′s role as a negative regulator of p53 function alongside MDM2. Pirh2′s ability to modulate p53 levels underscores its importance in cancer biology, making anti-Pirh2 antibody (C-12) an essential tool for researchers investigating pathways involved in tumorigenesis and protein interactions within the cell.

The preferred Pirh2 antibody is Pirh2 Antibody (D-12): sc-374505.