PINX1 Antibody (E-9): sc-374115

PINX1 Antibody (E-9) is a mouse monoclonal IgG1 antibody that detects PINX1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PINX1, also known as LPTL or LPTS, is a crucial protein that plays a significant role in telomere regulation and acts as a tumor suppressor. PINX1 is predominantly localized in nucleoli and telomere speckles, where PINX1 contains a G-patch domain and a telomeric inhibiting domain (TID) at its C-terminus. The TID domain is particularly important as PINX1 interacts specifically with the telomerase reverse transcriptase (TERT), inhibiting TERT activity and thereby regulating telomerase function. This inhibition is vital because overexpression of PINX1 can lead to shortened telomeres, which further supports PINX1′s role in controlling telomerase activity. Conversely, depletion of PINX1 results in increased telomerase activity, potentially contributing to the tumorigenicity of cancer cells. Thus, anti-PINX1 antibody (E-9) is an essential tool for researchers studying telomere dynamics, cancer biology, and the mechanisms of cell proliferation, providing insights into the tumor-suppressive functions of PINX1 and its involvement in nucleolar RNA maturation.

The preferred PINX1 antibody is PINX1 Antibody (D-3): sc-374113.