PIK3IP1 Antibody (B-12): sc-365778

PIK3IP1 Antibody (B-12) is a mouse monoclonal IgG1 antibody that detects PIK3IP1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PIK3IP1, also known as HGFL, is a 263 amino acid single-pass type I membrane protein characterized by the presence of one kringle domain, which plays a crucial role in its function. PIK3IP1 is primarily located in the cell membrane, where PIK3IP1 acts as a negative regulator of phosphoinositide 3-kinase (PI 3-kinase), a key signaling pathway involved in cell growth, proliferation, and survival. PIK3IP1′s regulation of PI 3-kinase is particularly important in the context of hepatocellular carcinoma, as PIK3IP1 helps suppress tumorigenesis associated with this pathway. The gene encoding PIK3IP1 is situated on human chromosome 22, a region significant for its role in various genetic disorders, including Phelan-McDermid syndrome and Neurofibromatosis type 2, and involvement in chromosomal translocations leading to the Philadelphia Chromosome associated with certain leukemias. Anti-PIK3IP1 antibody (B-12) is an essential tool for researchers studying the intricate mechanisms of cancer biology and the regulatory roles of signaling pathways in human health.

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PIK3IP1 Antibody (B-12) References:

1. PI3K is negatively regulated by PIK3IP1, a novel p110 interacting protein.  |  Zhu, Z., et al. 2007. Biochem Biophys Res Commun. 358: 66-72. PMID: 17475214
2. PIK3IP1, a negative regulator of PI3K, suppresses the development of hepatocellular carcinoma.  |  He, X., et al. 2008. Cancer Res. 68: 5591-8. PMID: 18632611
3. Inhibition of T-cell activation by PIK3IP1.  |  DeFrances, MC., et al. 2012. Eur J Immunol. 42: 2754-9. PMID: 22706993
4. Induction of prolonged early G1 arrest by CDK4/CDK6 inhibition reprograms lymphoma cells for durable PI3Kδ inhibition through PIK3IP1.  |  Chiron, D., et al. 2013. Cell Cycle. 12: 1892-900. PMID: 23676220
5. A cardiac myocyte-restricted Lin28/let-7 regulatory axis promotes hypoxia-mediated apoptosis by inducing the AKT signaling suppressor PIK3IP1.  |  Joshi, S., et al. 2016. Biochim Biophys Acta. 1862: 240-51. PMID: 26655604
6. Long non-coding RNA CCAT1/miR-148a axis promotes osteosarcoma proliferation and migration through regulating PIK3IP1.  |  Zhao, J. and Cheng, L. 2017. Acta Biochim Biophys Sin (Shanghai). 49: 503-512. PMID: 28549102
7. PIK3IP1/TrIP restricts activation of T cells through inhibition of PI3K/Akt.  |  Uche, UU., et al. 2018. J Exp Med. 215: 3165-3179. PMID: 30429249
8. RiPerC Attenuates Cerebral Ischemia Injury through Regulation of miR-98/PIK3IP1/PI3K/AKT Signaling Pathway.  |  Zhang, D., et al. 2020. Oxid Med Cell Longev. 2020: 6454281. PMID: 33082912
9. CircPDE5A-encoded novel regulator of the PI3K/AKT pathway inhibits esophageal squamous cell carcinoma progression by promoting USP14-mediated de-ubiquitination of PIK3IP1.  |  Lei, K., et al. 2024. J Exp Clin Cancer Res. 43: 124. PMID: 38658954
10. Downregulation of PIK3IP1/TrIP on T cells is controlled by TCR signal strength, PKC, and metalloprotease-mediated cleavage.  |  Murter, BM., et al. 2024. J Biol Chem. 300: 107930. PMID: 39454954

The preferred PIK3IP1 antibody is PIK3IP1 Antibody (B-1): sc-365777.