PICK1 Antibody (C-4): sc-74592
- PICK1 Antibody (C-4) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 1-300 mapping at the N-terminus of PICK1 of human origin
- recommended for detection of PICK1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PICK1 Antibody (C-4) for WB and IHC(P) applications. These reagents are now offered in bundles with PICK1 Antibody (C-4) (see ordering information below).
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PICK1 Antibody (C-4) is a mouse monoclonal IgG1 antibody that detects PICK1 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). PICK1, or protein interacting with C kinase 1, is a PDZ-domain containing protein predominantly located in the perinuclear region of cells, where PICK1 plays a crucial role in cellular signaling and synaptic transmission. The localization of PICK1 allows for precise regulation of interactions with other proteins, such as the α-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) receptor, which is essential for excitatory synaptic transmission. By anchoring AMPA receptors at specific synapses, PICK1 modulates synaptic strength and plasticity, processes vital for learning and memory. Additionally, PICK1 is phosphorylated in response to protein kinase C alpha (PKCα) activation, which is critical for regulation of cell proliferation and differentiation. The unique PDZ-binding domain of PKCα facilitates interaction with PICK1, and mutations in the PICK1 PDZ domain can disrupt this binding, highlighting the importance of this interaction in cellular signaling pathways. Anti-PICK1 antibody (C-4) is an invaluable tool for researchers studying PICK1′s intricate roles in synaptic modulation and neurobiology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PICK1 Antibody (C-4) References:
- PICK1 mediates synaptic recruitment of AMPA receptors at neurexin-induced postsynaptic sites. | Xu, J., et al. 2014. J Neurosci. 34: 15415-24. PMID: 25392508
- PICK1 Controls Activity-Dependent Synaptic Vesicle Cargo Retrieval. | Yong, XLH., et al. 2020. Cell Rep. 33: 108312. PMID: 33113376
- PICK1 Deficiency Exacerbates Sepsis-Associated Acute Kidney Injury. | Dou, Q., et al. 2021. Biomed Res Int. 2021: 9884297. PMID: 34307672
- Hypoxia-induced degradation of PICK1 by RBCK1 promotes the proliferation of nasopharyngeal carcinoma cells. | Zhang, Y., et al. 2023. Life Sci. 321: 121594. PMID: 36934971
- Truncating PICK1 Variant Identified in Azoospermia Affected Mitochondrial Dysfunction in Knockout Mice. | Du, YQ., et al. 2023. Curr Med Sci. 43: 313-323. PMID: 36971977
- PICK1-Deficient Mice Maintain Their Glucose Tolerance During Diet-Induced Obesity. | Backe, MB., et al. 2023. J Endocr Soc. 7: bvad057. PMID: 37200849
- Multi-omics study identifies that PICK1 deficiency causes male infertility by inhibiting vesicle trafficking in Sertoli cells. | Jin, J., et al. 2023. Reprod Biol Endocrinol. 21: 114. PMID: 38001535
- Targeting postsynaptic glutamate receptor scaffolding proteins PSD-95 and PICK1 for obesity treatment. | Fadahunsi, N., et al. 2024. Sci Adv. 10: eadg2636. PMID: 38427737
- PICK1 inhibits the malignancy of nasopharyngeal carcinoma and serves as a novel prognostic marker. | Ou, X., et al. 2024. Cell Death Dis. 15: 294. PMID: 38664379
- ICA1 affects APP processing through the PICK1-PKCα signaling pathway. | Ji, L., et al. 2024. CNS Neurosci Ther. 30: e14754. PMID: 38884369
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PICK1 Antibody (C-4) | sc-74592 | 200 µg/ml | $322.00 | |||
PICK1 Antibody (C-4): m-IgG Fc BP-HRP Bundle | sc-537231 | 200 µg Ab; 10 µg BP | $361.00 | |||
PICK1 Antibody (C-4): m-IgGκ BP-HRP Bundle | sc-534447 | 200 µg Ab; 40 µg BP | $361.00 | |||
PICK1 Antibody (C-4): m-IgG1 BP-HRP Bundle | sc-545093 | 200 µg Ab; 20 µg BP | $361.00 |