PIBF Antibody (G-10): sc-271504

PIBF Antibody (G-10) is a mouse monoclonal IgG1 antibody that detects Progesterone-Induced Blocking Factor 1 (PIBF) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PIBF plays a crucial role during pregnancy, as PIBF is synthesized in response to progesterone by progesterone receptor-positive T lymphocytes, predominantly gamma-delta T cells. PIBF is essential for modulating the immune response, particularly by inhibiting natural killer (NK) cells, which prevents the release of perforin and subsequent lysis of target cells. Notably, PIBF expression is significantly elevated in healthy pregnant women compared to those at risk for premature pregnancy termination, highlighting PIBF′s importance in maintaining pregnancy. PIBF gene encodes a hydrophilic protein consisting of 757 amino acids, featuring a variety of structural motifs, including an N-terminal signal sequence, a leucine zipper motif, and a nuclear localization signal, which are vital for function and localization within the cell. The full-length form of PIBF is associated with the nucleus and acts as a transcription factor, while shorter forms, which are secreted upon cell activation, may function as cytokines, further emphasizing PIBF′s multifaceted role in immune regulation and pregnancy maintenance. Anti-PIBF antibody (G-10) is an invaluable tool for researchers studying the intricate mechanisms of pregnancy and immune interactions.

The preferred PIBF antibody is PIBF Antibody (A-2): sc-376840.