PI 3-kinase p85α Antibody (C-1): sc-376112

PI 3-kinase p85α Antibody (C-1) is a mouse monoclonal IgG2b kappa light chain antibody targeting an epitope mapped between amino acids 7-43 near the N-terminus of human PI 3-kinase p85α, with species reactivity in mouse, rat, and human. PI 3-kinase p85α monoclonal antibody (C-1) is validated for applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). PI 3-kinase p85α, also known as PIK3R1 or phosphoinositide 3-kinase regulatory subunit alpha, is a structural component of the phosphatidylinositol 3-kinase (PI3K) complex. PI 3-kinase p85α serves as a regulatory adapter, linking the catalytic subunit p110 to activated receptor tyrosine kinases at the plasma membrane, where PI3K catalyzes the phosphorylation of phosphoinositides, a critical step in signal transduction. Structurally, PI 3-kinase p85α contains one SH3 domain and two SH2 domains, which are essential for interactions with phosphorylated tyrosine residues, ensuring proper localization and activation of the PI3K complex. These domains play a significant role in mediating interactions with other signaling proteins and regulating downstream pathways, such as the AKT/mTOR signaling cascade, which is involved in cell growth, metabolism, and survival. Dysregulation of PI3K activity, often due to mutations in PI 3-kinase p85α, is implicated in various cancers and metabolic disorders. Anti-PI 3-kinase p85α antibody (C-1) is a key tool for studying the structure-function relationship of PI 3-kinase p85α and its role in intracellular signaling and disease mechanisms.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PI 3-kinase p85α Antibody (C-1) has 11 citations in a variety of scientific publications.

Primary antibodies like Anti-PI 3-kinase p85α Antibody (C-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PI 3-kinase p85α Antibody (C-1) Specifications

Alternate Product Name: PI3K p85 alpha

Product Clone Name: C-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 7-43

Epitope Target: PI 3-kinase p85α

Epitope Species: human

Product Reactivity/Detection: PI 3-kinase p85α

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, bovine and avian

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 11 citations in various scientific publications

Available Conjugates/Forms for PI 3-kinase p85α Antibody (C-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred PI 3-kinase p85α antibody is PI 3-kinase p85α Antibody (B-9): sc-1637.