PGAM1 Antibody (6): sc-130334

PGAM1 Antibody (6) is a mouse monoclonal IgG1 kappa light chain antibody that detects PGAM1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-PGAM1 antibody (6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PGAM1 plays a crucial role in cellular metabolism, specifically in the interconversion of 3-phosphoglycerate and 2-phosphoglycerate, which are key intermediates in glycolysis and gluconeogenesis. This enzymatic activity is vital for maintaining energy homeostasis and supporting cellular functions, particularly in tissues with high metabolic demands. PGAM1, along with its isozyme PGAM2, can form homodimers or heterodimers, with PGAM1 predominantly expressed in various tissues while PGAM2 is primarily found in skeletal muscle, mature sperm cells, and the heart. The unique dimerization of these proteins allows for fine-tuning of metabolic pathways, making PGAM1 an important target for studying metabolic disorders and potential therapeutic interventions.

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PGAM1 Antibody (6) References:

1. Mouse phosphoglycerate mutase M and B isozymes: cDNA cloning, enzyme activity assay and mapping.  |  Zhang, J., et al. 2001. Gene. 264: 273-9. PMID: 11250083
2. Evolution of the phosphoglycerate mutase processed gene in human and chimpanzee revealing the origin of a new primate gene.  |  Betrán, E., et al. 2002. Mol Biol Evol. 19: 654-63. PMID: 11961099
3. A p21-activated kinase-controlled metabolic switch up-regulates phagocyte NADPH oxidase.  |  Shalom-Barak, T. and Knaus, UG. 2002. J Biol Chem. 277: 40659-65. PMID: 12189148
4. Glycolysis in Entamoeba histolytica. Biochemical characterization of recombinant glycolytic enzymes and flux control analysis.  |  Saavedra, E., et al. 2005. FEBS J. 272: 1767-83. PMID: 15794763
5. Characterization of the first described mutation of human red blood cell phosphoglycerate mutase.  |  de Atauri, P., et al. 2005. Biochim Biophys Acta. 1740: 403-10. PMID: 15949708
6. Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling.  |  Evans, MJ., et al. 2005. Nat Biotechnol. 23: 1303-7. PMID: 16200062
7. Proteomic analysis of secreted proteins of non-small cell lung cancer.  |  Huang, LJ., et al. 2006. Ai Zheng. 25: 1361-7. PMID: 17094902
8. Mechanistic and structural requirements for active site labeling of phosphoglycerate mutase by spiroepoxides.  |  Evans, MJ., et al. 2007. Mol Biosyst. 3: 495-506. PMID: 17579775
9. Screening cellular proteins binding to the core region of hepatitis C virus RNA genome with digoxin-labeled nucleic acids.  |  Su, HX., et al. 2007. Intervirology. 50: 303-9. PMID: 17622790

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PGAM1 Antibody (6) has 8 citations in a variety of scientific publications.

Primary antibodies like Anti-PGAM1 Antibody (6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PGAM1 Antibody (6) Specifications

Alternate Product Name: PGAM1

Product Clone Name: 6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: PGAM1

Epitope Species: human

Product Reactivity/Detection: PGAM1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 8 citations in various scientific publications

Available Conjugates/Forms for PGAM1 Antibody (6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin