Peroxin 11α Antibody (3B1): sc-293410

Peroxin 11α Antibody (3B1) is a mouse monoclonal IgG2a kappa light chain antibody that detects Peroxin 11 alpha protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Peroxin 11α antibody (3B1) is available as a non-conjugated format. Peroxin 11 alpha protein, also known as peroxisomal membrane protein 11A, plays a crucial role in peroxisome biogenesis and is essential for peroxisome proliferation and division, which are vital organelles involved in various metabolic processes, including fatty acid breakdown and hydrogen peroxide detoxification. Peroxin 11α functions as a multi-pass membrane protein consisting of 247 amino acids and localizes to peroxisome membrane, where Peroxin 11α interacts with coatomer proteins to regulate their binding, thereby influencing peroxisome dynamics. Peroxin 11α shows predominant expression in kidney, and Peroxin 11α gene is located on human chromosome 15q26.1. Proper functioning of Peroxin 11α remains critical for maintaining cellular homeostasis and metabolic balance, making Peroxin 11α an important target for research in metabolic disorders and peroxisomal diseases.

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Peroxin 11α Antibody (3B1) References:

1. PEX11alpha is required for peroxisome proliferation in response to 4-phenylbutyrate but is dispensable for peroxisome proliferator-activated receptor alpha-mediated peroxisome proliferation.  |  Li, X., et al. 2002. Mol Cell Biol. 22: 8226-40. PMID: 12417726
2. Peroxisome proliferator-activated receptor subtypes differentially cooperate with other transcription factors in selective transactivation of the perilipin/PEX11 alpha gene pair.  |  Shimizu, M., et al. 2006. J Biochem. 139: 563-73. PMID: 16567422
3. The PEROXIN11 protein family controls peroxisome proliferation in Arabidopsis.  |  Orth, T., et al. 2007. Plant Cell. 19: 333-50. PMID: 17220199
4. Clofibrate-inducible, 28-kDa peroxisomal integral membrane protein is encoded by PEX11.  |  Abe, I., et al. 1998. FEBS Lett. 431: 468-72. PMID: 9714566
5. Expression of PEX11beta mediates peroxisome proliferation in the absence of extracellular stimuli.  |  Schrader, M., et al. 1998. J Biol Chem. 273: 29607-14. PMID: 9792670

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Peroxin 11α Antibody (3B1) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Peroxin 11α Antibody (3B1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Peroxin 11α Antibody (3B1) Specifications

Alternate Product Name: Peroxin 11α

Product Clone Name: 3B1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-93

Epitope Target: Peroxin 11α

Epitope Species: human

Product Reactivity/Detection: Peroxin 11α

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Peroxin 11α Antibody (3B1): N/A