PELP1 Antibody (D-5): sc-393534

PELP1 Antibody (D-5) is a mouse monoclonal IgG1 antibody that detects PELP1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PELP1, or proline-, glutamic acid-, and leucine-rich protein-1, is a crucial coregulatory protein that significantly influences the activity of estrogen receptors, both in genomic and nongenomic pathways. PELP1 (D-5) antibody helps researchers study PELP1′s role in cancer progression, particularly in endometrial cancers, where PELP1 modulates the proliferation of cancerous endometrial cells. PELP1 is predominantly localized in the cytoplasm of high-grade endometrial tumors, where PELP1 interacts with estrogen receptor beta, highlighting PELP1′s importance in the tumor microenvironment. Furthermore, PELP1 not only coactivates estrogen receptor-mediated transcription but also acts as a corepressor for various nuclear hormone receptors and sequence-specific transcription factors, including glucocorticoid receptor, Nur77, AP1, NFkappaB, and TCF/SRF. This multifaceted role in transcriptional regulation and chromatin remodeling, particularly through the displacement of histone 1 in cancer cells, emphasizes PELP1′s significance in both normal and pathological states of the endometrium, making anti-PELP1 antibody (D-5) an invaluable tool for researchers studying PELP1′s diverse functions and implications in cancer biology.

The preferred PELP1 antibody is PELP1 Antibody (E-1): sc-390599.