CD31/PECAM-1 Antibody (E-4): sc-365804

PECAM-1 Antibody (E-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects PECAM-1 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-PECAM-1 antibody (E-4) is available in both non-conjugated and multiple conjugated forms, such as agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates. PECAM-1, also known as CD31, is a crucial glycoprotein that plays a significant role in mediating cell-cell adhesion, particularly in the vascular system, where PECAM-1 is expressed on the surfaces of endothelial cells, platelets, and certain leukocytes. PECAM-1 is essential for maintaining vascular integrity and facilitating leukocyte transmigration during inflammatory responses, which is vital for immune surveillance and tissue repair. PECAM-1 is involved in angiogenesis and the regulation of blood vessel permeability, making PECAM-1 a key player in both normal physiological processes and pathological conditions such as cancer metastasis and inflammatory diseases. PECAM-1′s interaction with other adhesion molecules, such as integrins, further underscores PECAM-1′s importance in cellular signaling and adhesion dynamics.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CD31/PECAM-1 Antibody (E-4) has 11 citations in a variety of scientific publications.

Primary antibodies like Anti-CD31/PECAM-1 Antibody (E-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CD31/PECAM-1 Antibody (E-4) Specifications

Alternate Product Name: CD31

Product Clone Name: E-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 712-738

Epitope Target: PECAM-1

Epitope Species: human

Product Reactivity/Detection: PECAM-1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 11 citations in various scientific publications

Available Conjugates/Forms for CD31/PECAM-1 Antibody (E-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred CD31/PECAM-1 antibody is CD31/PECAM-1 Antibody (MEC 13.3): sc-18916.