PDZK1 Antibody (H-1): sc-390932

PDZK1 Antibody (H-1) is a mouse monoclonal IgG1 antibody that detects PDZK1 in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PDZK1, also known as Diphor-1 in rats, is a crucial protein containing four PDZ domains, which are essential for organizing various ion channels and receptors at the plasma membrane of epithelial cells. This localization allows PDZK1 to facilitate interactions between multiple types of channels, playing a vital role in signal transduction and cellular communication. PDZK1′s function as an adaptor between different cell surface receptors is particularly important in maintaining cellular homeostasis and regulating ion transport. PDZK1 has been found to be markedly upregulated in human carcinomas of epithelial origin, suggesting involvement in cancer progression and potential contribution to multidrug resistance through interactions with proteins like MAP17 and cMOAT. Anti-PDZK1 antibody (H-1) serves as a valuable tool for researchers investigating cancer resistance mechanisms to chemotherapeutic agents and broader implications of PDZ domain-containing proteins in cellular signaling pathways.

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PDZK1 Antibody (H-1) References:

1. PDZK1, a novel PDZ domain-containing protein up-regulated in carcinomas and mapped to chromosome 1q21, interacts with cMOAT (MRP2), the multidrug resistance-associated protein.  |  Kocher, O., et al. 1999. Lab Invest. 79: 1161-70. PMID: 10496535
2. PDZK1 is required for maintaining hepatic scavenger receptor, class B, type I (SR-BI) steady state levels but not its surface localization or function.  |  Yesilaltay, A., et al. 2006. J Biol Chem. 281: 28975-80. PMID: 16867981
3. PDZK1/NHERF3 differentially regulates corticotropin-releasing factor receptor 1 and serotonin 2A receptor signaling and endocytosis.  |  Walther, C., et al. 2015. Cell Signal. 27: 519-31. PMID: 25562428
4. Beyond cholesterol homeostasis: A novel role for PDZK1 in macrophage apoptosis and atherosclerosis.  |  Karunakaran, D. 2018. Atherosclerosis. 276: 168-170. PMID: 30031591
5. PDZK1-interacting protein 1 (PDZK1IP1) traps Smad4 protein and suppresses transforming growth factor-β (TGF-β) signaling.  |  Ikeno, S., et al. 2019. J Biol Chem. 294: 4966-4980. PMID: 30718277
6. The nuclear receptors PXR and LXR are regulators of the scaffold protein PDZK1.  |  Ferreira, C., et al. 2019. Biochim Biophys Acta Gene Regul Mech. 1862: 447-456. PMID: 30831268
7. Sun exposure and PDZK1 genotype modulate PDZK1 gene expression in normal skin.  |  Hernando, B., et al. 2020. Photodermatol Photoimmunol Photomed. 36: 70-72. PMID: 31444921
8. Long noncoding RNA PENG upregulates PDZK1 expression by sponging miR-15b to suppress clear cell renal cell carcinoma cell proliferation.  |  Qi, Y., et al. 2020. Oncogene. 39: 4404-4420. PMID: 32341409
9. The individual and global impact of copy-number variants on complex human traits.  |  Auwerx, C., et al. 2022. Am J Hum Genet. 109: 647-668. PMID: 35240056
10. Apolipoprotein A1 Protects Against Necrotic Core Development in Atherosclerotic Plaques: PDZK1-Dependent High-Density Lipoprotein Suppression of Necroptosis in Macrophages.  |  Kluck, GEG., et al. 2023. Arterioscler Thromb Vasc Biol. 43: 45-63. PMID: 36353992

The preferred PDZK1 antibody is PDZK1 Antibody (F-36): sc-100337.