PDZK1 Antibody (F-36): sc-100337

PDZK1 Antibody (F-36) is a mouse monoclonal IgG1 kappa light chain antibody that detects PDZK1 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). PDZK1 (F-36) antibody is available in a non-conjugated form, allowing for versatile applications in various experimental settings. PDZK1 plays a crucial role in cellular signaling and organization, particularly in epithelial cells, where PDZK1 is localized to the plasma membrane. This strategic positioning enables PDZK1 to function as an adaptor protein, facilitating interactions between different types of ion channels and cell surface receptors through four PDZ domains. Such interactions are vital for maintaining cellular homeostasis and regulating ion transport, which is essential for numerous physiological processes. Notably, PDZK1 has been implicated in the development of multidrug resistance in human carcinomas of epithelial origin, as PDZK1 upregulation can enhance the clustering of proteins like cMOAT and MAP17, potentially contributing to therapeutic challenges in cancer treatment. Anti-PDZK1 antibody (F-36) enables researchers to explore PDZK1′s intricate roles in both normal physiology and disease states, making this antibody a valuable tool for advancing our understanding of cancer biology and drug resistance mechanisms.

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PDZK1 Antibody (F-36) References:

1. PDZK1, a novel PDZ domain-containing protein up-regulated in carcinomas and mapped to chromosome 1q21, interacts with cMOAT (MRP2), the multidrug resistance-associated protein.  |  Kocher, O., et al. 1999. Lab Invest. 79: 1161-70. PMID: 10496535
2. The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins.  |  Gentzsch, M., et al. 2003. J Biol Chem. 278: 6440-9. PMID: 12471024
3. Targeted disruption of the PDZK1 gene by homologous recombination.  |  Kocher, O., et al. 2003. Mol Cell Biol. 23: 1175-80. PMID: 12556478
4. PDZK1: I. a major scaffolder in brush borders of proximal tubular cells.  |  Gisler, SM., et al. 2003. Kidney Int. 64: 1733-45. PMID: 14531806
5. Role of the adaptor protein PDZK1 in controlling the HDL receptor SR-BI.  |  Kocher, O. and Krieger, M. 2009. Curr Opin Lipidol. 20: 236-41. PMID: 19421056
6. High density lipoprotein stimulated migration of macrophages depends on the scavenger receptor class B, type I, PDZK1 and Akt1 and is blocked by sphingosine 1 phosphate receptor antagonists.  |  Al-Jarallah, A., et al. 2014. PLoS One. 9: e106487. PMID: 25188469
7. SR-B1 and PDZK1: partners in HDL regulation.  |  Trigatti, BL. 2017. Curr Opin Lipidol. 28: 201-208. PMID: 28134663
8. Regulation of PDZ domain-containing 1 (PDZK1) expression by hepatocyte nuclear factor-1α (HNF1α) in human kidney.  |  Prestin, K., et al. 2017. Am J Physiol Renal Physiol. 313: F973-F983. PMID: 28724612
9. PDZK1 upregulates nitric oxide production through the PI3K/ERK2 pathway to inhibit porcine circovirus type 2 replication.  |  Pan, H., et al. 2022. Vet Microbiol. 272: 109514. PMID: 35917623
10. Downregulation of PDZK1 by TGF-β1 promotes renal fibrosis via inducing epithelial-mesenchymal transition of renal tubular cells.  |  Lu, S., et al. 2024. Biochem Pharmacol. 220: 116015. PMID: 38158021
11. PDZK1 suppresses TNBC development and sensitizes TNBC cells to erlotinib via the EGFR pathway.  |  Ma, Y., et al. 2024. Cell Death Dis. 15: 199. PMID: 38604999
12. PDZK1 protects against mechanical overload-induced chondrocyte senescence and osteoarthritis by targeting mitochondrial function.  |  Shao, Y., et al. 2024. Bone Res. 12: 41. PMID: 39019845

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PDZK1 Antibody (F-36) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-PDZK1 Antibody (F-36) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PDZK1 Antibody (F-36) Specifications

Alternate Product Name: PDZK1

Product Clone Name: F-36

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-520

Epitope Target: PDZK1

Epitope Species: human

Product Reactivity/Detection: PDZK1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 50 µg IgG₁ kappa light chain in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for PDZK1 Antibody (F-36): N/A