PDE2A Antibody (G-12): sc-271394

PDE2A Antibody (G-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects PDE2A protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). PDE2A (G-12) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PDE2A protein plays a crucial role in regulating intracellular levels of cyclic adenosine monophosphate (cAMP), a vital second messenger involved in numerous signaling pathways that control cellular functions such as metabolism, gene expression, and cell proliferation. By hydrolyzing cAMP to 5′AMP, PDE2A helps maintain the balance of cAMP signaling, which is essential for proper physiological responses. PDE2A protein is predominantly expressed in the cerebellum, neocortex, heart, kidney, placenta, lung, pulmonary artery, skeletal muscle, and pancreas, with notable expression in venous and capillary endothelial cells within cardiac and renal tissues. The ability of PDE2A to modulate cAMP levels highlights its importance in cardiovascular health and potential implications in various diseases, making anti-PDE2A antibody (G-12) a valuable tool for researchers studying these critical biological processes.

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PDE2A Antibody (G-12) References:

1. Differential expression of the cyclic GMP-stimulated phosphodiesterase PDE2A in human venous and capillary endothelial cells.  |  Sadhu, K., et al. 1999. J Histochem Cytochem. 47: 895-906. PMID: 10375378
2. Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase.  |  Hetman, JM., et al. 2000. Proc Natl Acad Sci U S A. 97: 472-6. PMID: 10618442
3. Phosphodiesterases PDE2A and PDE10A both change mRNA expression in the human brain with age, but only PDE2A changes in a region-specific manner with psychiatric disease.  |  Farmer, R., et al. 2020. Cell Signal. 70: 109592. PMID: 32119913
4. miR-139/PDE2A-Notch1 feedback circuit represses stemness of gliomas by inhibiting Wnt/β-catenin signaling.  |  Li, SZ., et al. 2021. Int J Biol Sci. 17: 3508-3521. PMID: 34512162
5. PDE2A Inhibition Enhances Axonal Sprouting, Functional Connectivity, and Recovery after Stroke.  |  Bechay, KR., et al. 2022. J Neurosci. 42: 8225-8236. PMID: 36163142
6. Radiosynthesis and Preclinical Evaluation of an 18F-Labeled Triazolopyridopyrazine-Based Inhibitor for Neuroimaging of the Phosphodiesterase 2A (PDE2A).  |  Wenzel, B., et al. 2022. Pharmaceuticals (Basel). 15: PMID: 36297384
7. Low Expression of Phosphodiesterase 2 (PDE2A) Promotes the Progression by Regulating Mitochondrial Morphology and ATP Content and Predicts Poor Prognosis in Hepatocellular Carcinoma.  |  Chen, L., et al. 2022. Cells. 12: PMID: 36611861
8. CRISPR/Cas9 Knock-Out in Primary Neonatal and Adult Cardiomyocytes Reveals Distinct cAMP Dynamics Regulation by Various PDE2A and PDE3A Isoforms.  |  Skryabin, EB., et al. 2023. Cells. 12: PMID: 37296663
9. Isolation and characterization of human cDNAs encoding a cGMP-stimulated 3',5'-cyclic nucleotide phosphodiesterase.  |  Rosman, GJ., et al. 1997. Gene. 191: 89-95. PMID: 9210593
10. Phosphodiesterase profile of human B lymphocytes from normal and atopic donors and the effects of PDE inhibition on B cell proliferation.  |  Gantner, F., et al. 1998. Br J Pharmacol. 123: 1031-8. PMID: 9559883
11. Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase.  |  Fisher, DA., et al. 1998. Biochem Biophys Res Commun. 246: 570-7. PMID: 9618252
12. Partial characterization of the active site human platelet cAMP phosphodiesterase, PDE3A, by site-directed mutagenesis.  |  Cheung, PP., et al. 1998. Arch Biochem Biophys. 360: 99-104. PMID: 9826434

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PDE2A Antibody (G-12) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-PDE2A Antibody (G-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PDE2A Antibody (G-12) Specifications

Alternate Product Name: PDE2A

Product Clone Name: G-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-300

Epitope Target: PDE2A

Epitope Species: human

Product Reactivity/Detection: PDE2A

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for PDE2A Antibody (G-12): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin