PCDH21 Antibody (G-9): sc-514574
- PCDH21 Antibody (G-9) is a mouse monoclonal IgG2b κ PCDH21 antibody provided at 200 µg/ml
- raised against amino acids 329-527 mapping within an internal region of PCDH21 of human origin
- PCDH21 Antibody (G-9) is recommended for detection of PCDH21 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-PCDH21 Antibody (G-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PCDH21 Antibody (G-9) for WB applications. These reagents are now offered in bundles with PCDH21 Antibody (G-9) (see ordering information below).
PCDH21 Antibody (G-9) is a mouse monoclonal IgG2b kappa light chain antibody that detects PCDH21 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PCDH21 (G-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PCDH21, also known as protocadherin 21, is a crucial component of the protocadherin family, which plays a significant role in cell adhesion and neuronal connectivity. PCDH21 is primarily localized to the outer segments of photoreceptor cells in the retina, where PCDH21 is essential for maintaining the structural integrity of these cells. The presence of six cadherin domains in PCDH21 facilitates calcium-dependent interactions that are vital for the formation and maintenance of synaptic connections in the nervous system. Additionally, PCDH21 exists in multiple alternatively spliced isoforms, which may contribute to functional diversity in neuronal networks. Understanding PCDH21′s role in cell adhesion and implications in retinal health underscores PCDH21′s importance in both basic research and potential therapeutic applications.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PCDH21 Antibody (G-9) References:
- Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes. | Wu, Q. and Maniatis, T. 2000. Proc Natl Acad Sci U S A. 97: 3124-9. PMID: 10716726
- Cadherin superfamily genes: functions, genomic organization, and neurologic diversity. | Yagi, T. and Takeichi, M. 2000. Genes Dev. 14: 1169-80. PMID: 10817752
- Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members. | Nollet, F., et al. 2000. J Mol Biol. 299: 551-72. PMID: 10835267
- Recent progress in protocadherin research. | Suzuki, ST. 2000. Exp Cell Res. 261: 13-8. PMID: 11082270
- Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. | Wu, Q., et al. 2001. Genome Res. 11: 389-404. PMID: 11230163
- A photoreceptor-specific cadherin is essential for the structural integrity of the outer segment and for photoreceptor survival. | Rattner, A., et al. 2001. Neuron. 32: 775-86. PMID: 11738025
- Protocadherin-21 (PCDH21), a candidate gene for human retinal dystrophies. | Bolz, H., et al. 2005. Mol Vis. 11: 929-33. PMID: 16288196
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PCDH21 Antibody (G-9) | sc-514574 | 200 µg/ml | $316.00 | |||
PCDH21 Antibody (G-9): m-IgG Fc BP-HRP Bundle | sc-531166 | 200 µg Ab; 10 µg BP | $354.00 | |||
PCDH21 Antibody (G-9): m-IgGκ BP-HRP Bundle | sc-524776 | 200 µg Ab, 40 µg BP | $354.00 | |||
PCDH21 Antibody (G-9): m-IgG2b BP-HRP Bundle | sc-550264 | 200 µg Ab; 10 µg BP | $354.00 | |||
PCDH21 Antibody (G-9) AC | sc-514574 AC | 500 µg/ml, 25% agarose | $416.00 | |||
PCDH21 Antibody (G-9) HRP | sc-514574 HRP | 200 µg/ml | $316.00 | |||
PCDH21 Antibody (G-9) FITC | sc-514574 FITC | 200 µg/ml | $330.00 | |||
PCDH21 Antibody (G-9) PE | sc-514574 PE | 200 µg/ml | $343.00 | |||
PCDH21 Antibody (G-9) Alexa Fluor® 488 | sc-514574 AF488 | 200 µg/ml | $357.00 | |||
PCDH21 Antibody (G-9) Alexa Fluor® 546 | sc-514574 AF546 | 200 µg/ml | $357.00 | |||
PCDH21 Antibody (G-9) Alexa Fluor® 594 | sc-514574 AF594 | 200 µg/ml | $357.00 | |||
PCDH21 Antibody (G-9) Alexa Fluor® 647 | sc-514574 AF647 | 200 µg/ml | $357.00 | |||
PCDH21 Antibody (G-9) Alexa Fluor® 680 | sc-514574 AF680 | 200 µg/ml | $357.00 | |||
PCDH21 Antibody (G-9) Alexa Fluor® 790 | sc-514574 AF790 | 200 µg/ml | $357.00 |