PCB Antibody (E-1): sc-373937

PCB Antibody (E-1) is a mouse monoclonal IgG2a antibody that detects pyruvate carboxylase (PCB) in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). PCB (E-1) antibody recognizes pyruvate carboxylase, a crucial mitochondrial enzyme responsible for catalyzing the conversion of pyruvate to oxaloacetate, a key step in gluconeogenesis and the citric acid cycle. This enzymatic function is vital for maintaining glucose homeostasis and energy production, particularly in tissues with high metabolic demands such as the liver and brain. Proper functioning of pyruvate carboxylase is essential, as deficiencies can lead to severe metabolic disorders, including lactic acidosis and hypoglycemia, which can have profound effects on neurological development and function. PCB (E-1) monoclonal antibody targets a protein encoded by a gene located on chromosome 11′s long arm, where mutations can disrupt enzymatic activity, highlighting PCB′s importance in metabolic regulation and potential as a therapeutic target.

The preferred PCB antibody is PCB Antibody (H-2): sc-271493.