Pbx 1a/2/3a Antibody (359.15): sc-101856

Pbx 1a/2/3a Antibody (359.15) is a mouse monoclonal IgG1 kappa light chain antibody that detects Pbx 1a/2/3a of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-Pbx 1a/2/3a antibody (359.15) is available as a non-conjugated format. Pbx proteins, including Pbx 1, Pbx 2, and Pbx 3, serve as essential members of the TALE (three amino acid loop extension) family of homeodomain-containing proteins, playing vital roles in regulating gene expression during development and differentiation. Pbx 1 forms a chimeric gene associated with human pre-B cell acute leukemias through chromosomal rearrangement, highlighting its significance in oncogenesis. Pbx proteins feature a homeodomain that enables DNA binding and transcription regulation, allowing interaction with various transcription factors to modulate target gene expression and influence cellular processes like proliferation, differentiation, and apoptosis. Pbx 2 and Pbx 3 share high sequence identity with Pbx 1 but show distinct expression patterns in lymphoid cells, which lack Pbx 1 expression. Widespread expression of Pbx genes in fetal and adult tissues emphasizes their fundamental role in maintaining cellular homeostasis and potential involvement in various diseases, including cancer.

The preferred Pbx 1b antibody is Pbx 1b Antibody (41.1): sc-101852.