Pbx 1b Antibody (41.1): sc-101852

Pbx 1b Antibody (41.1) is a mouse monoclonal IgG1 kappa light chain antibody that detects Pbx 1b protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-Pbx 1b antibody (41.1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Pbx 1b protein is a member of the TALE (three amino acid loop extension) family of homeodomain-containing proteins, which play crucial roles in regulating gene expression during development and differentiation. Pbx proteins are involved in forming protein complexes that interact with other transcription factors, such as E2A, which is significant in pre-B cell acute leukemia, where chromosomal rearrangement can lead to fusion gene creation contributing to oncogenesis. Pbx 1b protein is ubiquitously expressed in both fetal and adult tissues, highlighting an essential role in various biological processes. Pbx 2 and Pbx 3 transcripts are found in lymphoid cells, while Pbx 4 expression is specifically localized to testis, particularly in spermatocytes during pachytene stage of meiosis. This diverse expression pattern underscores Pbx proteins′ importance in developmental biology and potential implications in cancer research.

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Pbx 1b Antibody (41.1) References:

1. Expression of Meis and Pbx genes and their protein products in the developing telencephalon: implications for regional differentiation.  |  Toresson, H., et al. 2000. Mech Dev. 94: 183-7. PMID: 10842069
2. Expression of Pbx1b during mammalian organogenesis.  |  Schnabel, CA., et al. 2001. Mech Dev. 100: 131-5. PMID: 11118899
3. Pbx4, a new Pbx family member on mouse chromosome 8, is expressed during spermatogenesis.  |  Wagner, K., et al. 2001. Mech Dev. 103: 127-31. PMID: 11335119
4. Activation of the rat renin promoter by HOXD10.PBX1b.PREP1, Ets-1, and the intracellular domain of notch.  |  Pan, L., et al. 2005. J Biol Chem. 280: 20860-6. PMID: 15792957
5. PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1.  |  Monica, K., et al. 1991. Mol Cell Biol. 11: 6149-57. PMID: 1682799
6. Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor.  |  Nourse, J., et al. 1990. Cell. 60: 535-45. PMID: 1967982
7. A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL.  |  Kamps, MP., et al. 1990. Cell. 60: 547-55. PMID: 1967983
8. Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation.  |  Lu, Q., et al. 1994. Mol Cell Biol. 14: 3938-48. PMID: 7910944
9. Transformation properties of the E2a-Pbx1 chimeric oncoprotein: fusion with E2a is essential, but the Pbx1 homeodomain is dispensable.  |  Monica, K., et al. 1994. Mol Cell Biol. 14: 8304-14. PMID: 7969166
10. Fusion with E2A alters the transcriptional properties of the homeodomain protein PBX1 in t(1;19) leukemias.  |  LeBrun, DP. and Cleary, ML. 1994. Oncogene. 9: 1641-7. PMID: 8183558
11. Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b.  |  Kroon, E., et al. 1998. EMBO J. 17: 3714-25. PMID: 9649441
12. An endocrine-exocrine switch in the activity of the pancreatic homeodomain protein PDX1 through formation of a trimeric complex with PBX1b and MRG1 (MEIS2).  |  Swift, GH., et al. 1998. Mol Cell Biol. 18: 5109-20. PMID: 9710595

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Pbx 1b Antibody (41.1) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-Pbx 1b Antibody (41.1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Pbx 1b Antibody (41.1) Specifications

Alternate Product Name: PBX1

Product Clone Name: 41.1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 319-347

Epitope Target: Pbx 1b

Epitope Species: human

Product Reactivity/Detection: Pbx 1b

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for Pbx 1b Antibody (41.1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin