PBK Antibody (F-7): sc-390790

PBK Antibody (F-7) is a mouse monoclonal IgG1 antibody that detects PBK in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PBK, or human PDZ-binding kinase, is a 322 amino acid serine/threonine kinase characterized by its T/SXV motif, which plays a crucial role in regulating various cellular processes, particularly in cell cycle control and proliferation. PBK is predominantly expressed in the placenta and is notably absent in adult brain tissue, highlighting its specific functional relevance in reproductive biology. PBK′s interaction with PDZ domain-containing proteins, such as the tumor suppressor protein Dlg, underscores PBK′s importance in cellular signaling pathways that govern cell cycle checkpoints. Additionally, PBK is activated by upstream effectors like the Cdc2/cyclin B complex, which phosphorylates PBK, thereby modulating PBK activity and influencing downstream cellular responses. PBK′s ability to associate with other proteins involved in cell cycle regulation makes PBK a significant target for understanding oncogenic processes and potential therapeutic interventions. Anti-PBK antibody (F-7) is an essential tool for researchers investigating the intricate roles of this kinase in various biological contexts.

The preferred PBK antibody is PBK Antibody (B-10): sc-390399.