PBK Antibody (C-3): sc-390812
- PBK Antibody (C-3) is a mouse monoclonal IgM κ provided at 200 µg/ml
- raised against amino acids 19-252 mapping near the N-terminus of PBK of human origin
- recommended for detection of PBK of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PBK Antibody (C-3). This work is in progress.
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SEE ALSO...
PBK Antibody (C-3) is a mouse monoclonal IgM antibody that detects PBK in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PBK, or human PDZ-binding kinase, is a 322 amino acid serine/threonine kinase characterized by its T/SXV motif, which plays a crucial role in regulating cellular processes by catalyzing the transfer of phosphate groups to specific amino acid residues. This phosphorylation is vital for modulating the activity of various oncoproteins and tumor suppressor proteins, thereby influencing the oncogenic potential of cells. Notably, PBK is predominantly expressed in the placenta and is absent from adult brain tissue, highlighting its specialized function in reproductive tissues. The interaction between PBK and PDZ domain-containing proteins, such as the tumor suppressor Dlg, underscores its importance in cell cycle regulation and cellular proliferation. Additionally, the upstream kinase Cdc2/cyclin B can phosphorylate and activate PBK, further linking it to critical cell cycle checkpoints. Anti-PBK antibody (C-3) is an essential tool for researchers investigating the intricate roles of PBK in cellular signaling and cancer biology.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PBK Antibody (C-3) | sc-390812 | 200 µg/ml | $322.00 |