Pancreatic Lipase Antibody (A-3): sc-374612

Pancreatic Lipase Antibody (A-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects Pancreatic Lipase protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Pancreatic Lipase (A-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Pancreatic Lipase, also known as pancreatic triacylglycerol acyl hydrolase, is primarily located in the pancreas and plays a vital role in lipid metabolism by hydrolyzing triglycerides into diglycerides, monoglycerides, and free fatty acids, which are essential for the absorption of dietary fats. This enzymatic activity is crucial for proper digestion and nutrient absorption, as Pancreatic Lipase facilitates the breakdown of fats in the small intestine, allowing for their subsequent uptake by intestinal cells. Understanding the function and regulation of Pancreatic Lipase is essential for developing therapeutic strategies aimed at addressing conditions related to lipid metabolism, as dysfunction can lead to malabsorption syndromes and contribute to various metabolic disorders.

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Pancreatic Lipase Antibody (A-3) References:

1. Fat absorption in cystic fibrosis mice is impeded by defective lipolysis and post-lipolytic events.  |  Bijvelds, MJ., et al. 2005. Am J Physiol Gastrointest Liver Physiol. 288: G646-53. PMID: 15528257
2. The desmoplastic melanocytic naevus: a distinct histological entity.  |  Mackie, RM. and Doherty, VR. 1992. Histopathology. 20: 207-11. PMID: 1563707
3. Screening of some medicinal plants for anti-lipase activity.  |  Sharma, N., et al. 2005. J Ethnopharmacol. 97: 453-6. PMID: 15740880
4. Anti-obesity effects of chikusetsusaponins isolated from Panax japonicus rhizomes.  |  Han, LK., et al. 2005. BMC Complement Altern Med. 5: 9. PMID: 15811191
5. Prevention of diet-induced obesity by dietary isomerized hop extract containing isohumulones, in rodents.  |  Yajima, H., et al. 2005. Int J Obes (Lond). 29: 991-7. PMID: 15852044
6. Structure of human pancreatic lipase.  |  Winkler, FK., et al. 1990. Nature. 343: 771-4. PMID: 2106079
7. Cloning and characterization of human pancreatic lipase cDNA.  |  Lowe, ME., et al. 1989. J Biol Chem. 264: 20042-8. PMID: 2479644
8. Polyphenolic Compounds as Pancreatic Lipase Inhibitors.  |  Buchholz, T. and Melzig, MF. 2015. Planta Med. 81: 771-83. PMID: 26132857
9. Inhibitors of pancreatic lipase: state of the art and clinical perspectives.  |  Lunagariya, NA., et al. 2014. EXCLI J. 13: 897-921. PMID: 26417311
10. Pancreatic lipase inhibitory activity of selected pharmaceutical agents.  |  Hamdan, II., et al. 2019. Acta Pharm. 69: 1-16. PMID: 31259721
11. Targeting obesity with plant-derived pancreatic lipase inhibitors: A comprehensive review.  |  Rajan, L., et al. 2020. Pharmacol Res. 155: 104681. PMID: 32045666
12. Proanthocyanidins as the main pancreatic lipase inhibitors in chokeberry fruits.  |  Sosnowska, D., et al. 2022. Food Funct. 13: 5616-5625. PMID: 35506494

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Pancreatic Lipase Antibody (A-3) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-Pancreatic Lipase Antibody (A-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Pancreatic Lipase Antibody (A-3) Specifications

Alternate Product Name: Pancreatic Lipase

Product Clone Name: A-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 260-300

Epitope Target: Pancreatic Lipase

Epitope Species: human

Product Reactivity/Detection: Pancreatic Lipase, and Pancreatic Lipase Related Protein 1 and 2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for Pancreatic Lipase Antibody (A-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin