pan-Cytokeratin Antibody (AE1/AE3): sc-81714

pan-Cytokeratin Antibody (AE1/AE3) is a mouse monoclonal IgG1 kappa light chain antibody that detects pan-Cytokeratin across multiple species including mouse, rat, human, bovine, and rabbit, by applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). anti-pan-Cytokeratin antibody (AE1/AE3) is available in both conjugated and non-conjugated forms, providing flexibility for various experimental needs. Cytokeratins, recognized by pan-Cytokeratin monoclonal antibody (AE1/AE3), are a vital group of intermediate filament proteins that maintain the structural integrity of epithelial cells. These proteins are expressed in pairs and are essential for cellular differentiation and tissue specialization, making them particularly valuable in cancer research. Specific cytokeratins serve as reliable biomarkers for distinguishing between different types of tumors; cytokeratins 10 and 13 are frequently elevated in certain squamous cell carcinomas, while cytokeratin 18 is predominantly expressed in adenocarcinomas and basal cell carcinomas. Expression patterns of cytokeratins help characterize malignant tumors and provide insights into epithelial cell function and pathology.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-pan-Cytokeratin Antibody (AE1/AE3) has 76 citations in a variety of scientific publications.

Primary antibodies like Anti-pan-Cytokeratin Antibody (AE1/AE3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

pan-Cytokeratin Antibody (AE1/AE3) Specifications

Alternate Product Name: Cytokeratin

Product Clone Name: AE1/AE3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: pan-Cytokeratin

Epitope Species: human

Product Reactivity/Detection: most acidic (type I) and basic (type II) Cytokeratins

Species Reactivity/Detection: mouse, rat, human, bovine, rabbit

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 76 citations in various scientific publications

Available Conjugates/Forms for pan-Cytokeratin Antibody (AE1/AE3): HRP: Horseradish Peroxidase

The preferred pan-Cytokeratin antibody is pan-Cytokeratin Antibody (C11): sc-8018.