pan cathepsin Antibody (D-2): sc-377017
- pan cathepsin Antibody (D-2) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 107-145 near the N-terminus of cathepsin of human origin
- recommended for detection of a broad range of cathepsin proteins of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for pan cathepsin Antibody (D-2) for WB and IHC(P) applications. These reagents are now offered in bundles with pan cathepsin Antibody (D-2) (see ordering information below).
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Pan cathepsin Antibody (D-2) is a mouse monoclonal IgG2a antibody that detects pan cathepsin in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-pan cathepsin antibody (D-2) targets a crucial family of proteolytic enzymes known as cathepsins, which play significant roles in cellular metabolism, including peptide biosynthesis and protein degradation. Cathepsin L is particularly noteworthy due to structural similarity to cathepsin H, and is primarily localized in lysosomes, where cathepsin L is involved in degradation of extracellular matrix components and processing of antigenic peptides for presentation by major histocompatibility complex (MHC) molecules. This localization is vital for maintaining cellular homeostasis and regulating immune responses, as dysregulation of cathepsin activity has been implicated in various diseases, including cancer and neurodegenerative disorders. Pan cathepsin (D-2) antibody serves as an essential tool for researchers investigating the roles of these proteases in health and disease, enabling a deeper understanding of their functions and interactions within the cellular environment.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
pan cathepsin Antibody (D-2) References:
- Calcium-independent phospholipase A2 beta is dispensable in inflammasome activation and its inhibition by bromoenol lactone. | Franchi, L., et al. 2009. J Innate Immun. 1: 607-17. PMID: 20160900
- TBX2 represses CST6 resulting in uncontrolled legumain activity to sustain breast cancer proliferation: a novel cancer-selective target pathway with therapeutic opportunities. | D'Costa, ZC., et al. 2014. Oncotarget. 5: 1609-20. PMID: 24742492
- Upregulated Autophagy in Sertoli Cells of Ethanol-Treated Rats Is Associated with Induction of Inducible Nitric Oxide Synthase (iNOS), Androgen Receptor Suppression and Germ Cell Apoptosis. | Horibe, A., et al. 2017. Int J Mol Sci. 18: PMID: 28505146
- mTORC1 activation in B cells confers impairment of marginal zone microarchitecture by exaggerating cathepsin activity. | Meena, NK., et al. 2018. Immunology. 155: 505-518. PMID: 30144045
- Hyperbaric oxygen significantly improves frequent urination, hyperalgesia, and tissue damage in a mouse long-lasting cystitis model induced by an intravesical instillation of hydrogen peroxide. | Minami, A., et al. 2019. Neurourol Urodyn. 38: 97-106. PMID: 30411813
- Ethanol-Induced Mitochondrial Damage in Sertoli Cells is Associated with Parkin Overexpression and Activation of Mitophagy. | Eid, N., et al. 2019. Cells. 8: PMID: 30934625
- Cathepsin L Regulates Metabolic Networks Controlling Rapid Cell Growth and Proliferation. | Weiss-Sadan, T., et al. 2019. Mol Cell Proteomics. 18: 1330-1344. PMID: 31010818
- The Pyroptotic Cell Death Effector Gasdermin D Is Activated by Gout-Associated Uric Acid Crystals but Is Dispensable for Cell Death and IL-1β Release. | Rashidi, M., et al. 2019. J Immunol. 203: 736-748. PMID: 31209100
- Lysosomal disruption by orthopedic wear particles induces activation of the NLRP3 inflammasome and macrophage cell death by distinct mechanisms. | Fort, BP., et al. 2021. J Orthop Res. 39: 493-505. PMID: 32779803
- ASO-mediated knockdown of GPNMB in mutant- GRN and Grn -deficient peripheral myeloid cells disrupts lysosomal function and immune responses. | Wallings, RL., et al. 2024. bioRxiv.. PMID: 39211224
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
pan cathepsin Antibody (D-2) | sc-377017 | 200 µg/ml | $316.00 | |||
pan cathepsin Antibody (D-2): m-IgG Fc BP-HRP Bundle | sc-538018 | 200 µg Ab; 10 µg BP | $354.00 | |||
pan cathepsin Antibody (D-2): m-IgGκ BP-HRP Bundle | sc-535537 | 200 µg Ab; 40 µg BP | $354.00 | |||
pan cathepsin Antibody (D-2): m-IgG2a BP-HRP Bundle | sc-548185 | 200 µg Ab; 10 µg BP | $354.00 | |||
pan cathepsin (D-2) Neutralizing Peptide | sc-377017 P | 100 µg/0.5 ml | $68.00 |