p57 Kip2 Antibody (SPM308): sc-56456
- p57 Kip2 Antibody (SPM308) is a mouse monoclonal IgG2b κ, cited in 2 publications, provided at 200 µg/ml
- raised against recombinant p57Kip2Kip2 protein of human origin
- recommended for detection of p57 Kip2 of mouse, rat and human origin by WB, IP, IF and IHC(P)
- See p57 Kip2 (KP39): sc-56341 for p57 Kip2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for p57 Kip2 Antibody (SPM308) for WB and IHC(P) applications. These reagents are now offered in bundles with p57 Kip2 Antibody (SPM308) (see ordering information below).
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p57 Kip2 Antibody (SPM308) is a mouse monoclonal IgG2b antibody that detects p57 Kip2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. p57 Kip2, also known as Kip2, is a crucial member of the p21 Waf1/Cip1 family of cyclin-dependent kinase inhibitors, playing a significant role in regulating cell cycle progression by inhibiting several G1 cyclin/Cdk complexes. This inhibition is vital for maintaining proper cell cycle control, particularly in response to cellular stress or developmental signals. Unlike p21 Waf1/Cip1, p57 Kip2 is not regulated by p53, which allows p57 Kip2 to function independently in various cellular contexts. p57 Kip2′s ability to tightly bind and inhibit cyclin/Cdk complexes makes p57 Kip2 a potent regulator of G1 phase progression, and p57 Kip2 overexpression can lead to cell cycle arrest in G1, highlighting p57 Kip2′s importance in tumor suppression and cellular differentiation. Anti-p57 Kip2 antibody (SPM308) is an essential tool for researchers studying cell cycle dynamics, cancer biology, and the mechanisms of cellular regulation.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p57 Kip2 Antibody (SPM308) | sc-56456 | 200 µg/ml | $322.00 | |||
p57 Kip2 Antibody (SPM308): m-IgG Fc BP-HRP Bundle | sc-537099 | 200 µg Ab; 10 µg BP | $361.00 | |||
p57 Kip2 Antibody (SPM308): m-IgGκ BP-HRP Bundle | sc-534290 | 200 µg Ab; 40 µg BP | $361.00 | |||
p57 Kip2 Antibody (SPM308): m-IgG2b BP-HRP Bundle | sc-549854 | 200 µg Ab; 10 µg BP | $361.00 |