p54/nrb Antibody (A-9): sc-166704

p54/nrb Antibody (A-9) is a mouse monoclonal IgG2a antibody that detects p54/nrb in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). p54/nrb, also known as nuclear RNA-binding protein, plays a crucial role in the regulation of gene expression by participating in the formation and function of paraspeckles, which are nuclear bodies involved in the storage and processing of RNA. These structures are essential for maintaining cellular homeostasis and responding to stress, as they sequester specific RNA molecules and proteins, thereby influencing RNA metabolism and gene regulation. The dynamic movement of p54/nrb between the nucleolus and paraspeckles highlights its importance in cellular signaling and transcriptional regulation, particularly under conditions where transcription is inhibited. With its two RNA recognition motifs and shared DBHS domain, p54/nrb interacts with other splicing factors, contributing to the intricate network of RNA processing and splicing pathways. p54/nrb Antibody (A-9) is an invaluable tool for researchers studying RNA biology, gene expression regulation, and the cellular response to various stimuli.

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p54/nrb Antibody (A-9) References:

1. p54nrb/NonO and PSF promote U snRNA nuclear export by accelerating its export complex assembly.  |  Izumi, H., et al. 2014. Nucleic Acids Res. 42: 3998-4007. PMID: 24413662
2. Furospinosulin-1, Marine Spongean Furanosesterterpene, Suppresses the Growth of Hypoxia-Adapted Cancer Cells by Binding to Transcriptional Regulators p54(nrb) and LEDGF/p75.  |  Arai, M., et al. 2016. Chembiochem. 17: 181-9. PMID: 26561285
3. Structure, Dynamics, and Interaction of p54(nrb)/NonO RRM1 with 5' Splice Site RNA Sequence.  |  Duvignaud, JB., et al. 2016. Biochemistry. 55: 2553-66. PMID: 27064654
4. Nuclear scaffold protein p54nrb/NONO facilitates the hypoxia-enhanced progression of hepatocellular carcinoma.  |  Shen, M., et al. 2021. Oncogene. 40: 4167-4183. PMID: 34079086
5. Reversible acetylation modulates p54nrb/NONO-mediated expression of the interleukin 8 gene.  |  Ryu, JE., et al. 2022. Biochem Biophys Res Commun. 622: 50-56. PMID: 35843094
6. LncRNA Neat1 targets NonO and miR-128-3p to promote antigen-specific Th17 cell responses and autoimmune inflammation.  |  Chen, S., et al. 2023. Cell Death Dis. 14: 610. PMID: 37716986
7. Nucleolar detention of NONO shields DNA double-strand breaks from aberrant transcripts.  |  Trifault, B., et al. 2024. Nucleic Acids Res. 52: 3050-3068. PMID: 38224452
8. Non-O blood types are associated with a greater risk of large artery atherosclerosis stroke and dysregulation of cholesterol metabolism: an observational study.  |  Gou, L., et al. 2024. Lipids Health Dis. 23: 211. PMID: 38965603
9. LncRNA GClnc1 promotes osteosarcoma progression by stabilizing NONO and blocking FBXW7-mediated ubiquitination.  |  Zhang, J., et al. 2024. BMC Cancer. 24: 1375. PMID: 39523321
10. A novel nuclear RNA HSD52 scaffolding NONO/SFPQ complex modulates DNA damage repair to facilitate temozolomide resistance.  |  Sun, N., et al. 2024. Neuro Oncol.. PMID: 39673809

The preferred p54/nrb antibody is p54/nrb Antibody (G-1): sc-376865.