p44S10 Antibody (H-5): sc-398745
- p44S10 Antibody (H-5) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 31-69 near the N-terminus of p44S10 of human origin
- recommended for detection of p44S10 of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for p44S10 Antibody (H-5) for WB applications. These reagents are now offered in bundles with p44S10 Antibody (H-5) (see ordering information below).
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p44S10 Antibody (H-5) is a mouse monoclonal IgG1 antibody that detects p44S10 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). p44S10, a highly conserved regulatory subunit of the 26S proteasome, plays a crucial role in the selective degradation of cellular proteins, a process vital for maintaining cellular homeostasis and regulating various cellular functions. p44S10 is predominantly expressed in key tissues such as the heart, liver, skeletal muscle, and pancreas, highlighting its importance in metabolic and physiological processes. p44S10 is also found in several melanoma cell lines, including MCF-7, 451Lu, and WM164, where forced expression has been linked to increased cellular proliferation. This suggests that p44S10 may serve as a significant link between proteasome activity regulation and tumor cell growth, making p44S10 a potential target for therapeutic interventions in cancer. p44S10 (H-5) antibody is an essential tool for researchers investigating the dynamics of proteasome function and its implications in both normal physiology and disease states.
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p44S10 Antibody (H-5) References:
- The p44S10 locus, encoding a subunit of the proteasome regulatory particle, is amplified during progression of cutaneous malignant melanoma. | Ren, S., et al. 2000. Oncogene. 19: 1419-27. PMID: 10723133
- Transcription factor complexes. | Burley, SK. and Kamada, K. 2002. Curr Opin Struct Biol. 12: 225-30. PMID: 11959501
- A combination of molecular cytogenetic analyses reveals complex genetic alterations in conventional renal cell carcinoma. | Strefford, JC., et al. 2005. Cancer Genet Cytogenet. 159: 1-9. PMID: 15860350
- Switching fatty acid metabolism by an RNA-controlled feed forward loop. | Huber, M., et al. 2020. Proc Natl Acad Sci U S A. 117: 8044-8054. PMID: 32193348
- The Canonical Long-Chain Fatty Acid Sensing Machinery Processes Arachidonic Acid To Inhibit Virulence in Enterohemorrhagic Escherichia coli. | Ellermann, M., et al. 2021. mBio. 12: PMID: 33468701
- A comparative study of evaluating missing value imputation methods in label-free proteomics. | Jin, L., et al. 2021. Sci Rep. 11: 1760. PMID: 33469060
- A Ratiometric Fluorescent Biosensor Reveals Dynamic Regulation of Long-Chain Fatty Acyl-CoA Esters Metabolism. | Wang, W., et al. 2021. Angew Chem Int Ed Engl. 60: 13996-14004. PMID: 33837610
- Chemical biology-whole genome engineering datasets predict new antibacterial combinations. | Turner, AK., et al. 2021. Microb Genom. 7: PMID: 34874820
- Fatty acid overproduction by gut commensal microbiota exacerbates obesity. | Takeuchi, T., et al. 2023. Cell Metab. 35: 361-375.e9. PMID: 36652945
- Role of long-chain fatty acyl-CoA esters in the regulation of metabolism and in cell signalling. | Faergeman, NJ. and Knudsen, J. 1997. Biochem J. 323 (Pt 1): 1-12. PMID: 9173866
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p44S10 Antibody (H-5) | sc-398745 | 200 µg/ml | $322.00 | |||
p44S10 Antibody (H-5): m-IgG Fc BP-HRP Bundle | sc-538514 | 200 µg Ab; 10 µg BP | $361.00 | |||
p44S10 Antibody (H-5): m-IgGκ BP-HRP Bundle | sc-536140 | 200 µg Ab; 40 µg BP | $361.00 | |||
p44S10 Antibody (H-5): m-IgG1 BP-HRP Bundle | sc-545743 | 200 µg Ab; 20 µg BP | $361.00 | |||
p44S10 (H-5) Neutralizing Peptide | sc-398745 P | 100 µg/0.5 ml | $69.00 |