CDKN1B/Kip1 p27 Antibody (A-10): sc-393380
- CDKN1B/Kip1 p27 Antibody (A-10) is a mouse monoclonal IgG2b κ, cited in 14 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 157-198 at the C-terminus of p27 Kip1 of human origin
- recommended for detection of p27 Kip1 of mouse, rat and human origin by WB, IP, IF and ELISA
- See CDKN1B/Kip1 p27 (F-8): sc-1641 for CDKN1B/Kip1 p27 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CDKN1B/Kip1 p27 Antibody (A-10) for WB applications. These reagents are now offered in bundles with CDKN1B/Kip1 p27 Antibody (A-10) (see ordering information below).
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p27 Kip1 Antibody (A-10) is a mouse monoclonal IgG2b antibody that detects p27 Kip1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). p27 Kip1 plays a crucial role in regulating the cell cycle by acting as a negative regulator of G1 progression, which is essential for maintaining proper cellular function and preventing uncontrolled cell proliferation. p27 Kip1 is particularly important in cancer biology, as p27 Kip1 levels are often altered in various tumors, leading to dysregulation of the cell cycle. p27 Kip1 interacts strongly with D-type cyclins and cyclin-dependent kinase 4 (Cdk4), which is vital for the transition from the G1 phase to the S phase of the cell cycle. Additionally, p27 Kip1 is influenced by various post-translational modifications, including phosphorylation, which can affect stability and activity. p27 Kip1′s ability to mediate TGFβ-induced G1 arrest further underscores significance in cellular responses to growth factors and stress signals. With diverse roles in cell cycle regulation and tumor suppression, anti-p27 Kip1 antibody (A-10) serves as an invaluable tool for researchers studying cancer and cell biology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CDKN1B/Kip1 p27 Antibody (A-10) References:
- p27(Kip1) is important in modulating pulmonary artery smooth muscle cell proliferation. | Fouty, BW., et al. 2001. Am J Respir Cell Mol Biol. 25: 652-8. PMID: 11713109
- p27 Kip1 protein expression in Hashimoto's thyroiditis. | Troncone, G., et al. 2003. J Clin Pathol. 56: 587-91. PMID: 12890807
- p27(Kip1) Knockout mice are protected from diabetic nephropathy: evidence for p27(Kip1) haplotype insufficiency. | Wolf, G., et al. 2005. Kidney Int. 68: 1583-9. PMID: 16164635
- p27(Kip1) negatively regulates the activation of murine primordial oocytes. | Hirashima, Y., et al. 2011. J Reprod Dev. 57: 217-22. PMID: 21157123
- p27(Kip1) V109G polymorphism and cancer risk: a systematic review and meta-analysis. | Wei, F., et al. 2012. Cancer Biother Radiopharm. 27: 665-71. PMID: 22823061
- p27(Kip1) negatively regulates the magnitude and persistence of CD4 T cell memory. | Jatzek, A., et al. 2012. J Immunol. 189: 5119-28. PMID: 23071285
- p27(Kip1) directly represses Sox2 during embryonic stem cell differentiation. | Li, H., et al. 2012. Cell Stem Cell. 11: 845-52. PMID: 23217425
- TRIP6 regulates p27 KIP1 to promote tumorigenesis. | Lin, VT., et al. 2013. Mol Cell Biol. 33: 1394-409. PMID: 23339869
- Immunohistochemically detected expression of Skp2, p27 kip1, and p-p27 (Thr187) in patients with cholangiocarcinoma. | Luo, J., et al. 2015. Tumour Biol. 36: 5119-25. PMID: 25663461
- p27(Kip1) participates in the regulation of endoreplication in differentiating chick retinal ganglion cells. | Ovejero-Benito, MC. and Frade, JM. 2015. Cell Cycle. 14: 2311-22. PMID: 25946375
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CDKN1B/Kip1 p27 Antibody (A-10) | sc-393380 | 200 µg/ml | $322.00 | |||
CDKN1B/Kip1 p27 Antibody (A-10): m-IgG Fc BP-HRP Bundle | sc-538200 | 200 µg Ab; 10 µg BP | $361.00 | |||
CDKN1B/Kip1 p27 Antibody (A-10): m-IgGκ BP-HRP Bundle | sc-535768 | 200 µg Ab; 40 µg BP | $361.00 | |||
CDKN1B/Kip1 p27 Antibody (A-10): m-IgG2b BP-HRP Bundle | sc-549925 | 200 µg Ab; 10 µg BP | $361.00 | |||
CDKN1B/Kip1 p27 (A-10) Neutralizing Peptide | sc-393380 P | 100 µg/0.5 ml | $69.00 |