Waf1/Cip1/CDKN1A p21 Antibody (SX118): sc-53870

p21 Waf1/Cip1 Antibody (SX118) is a mouse monoclonal IgG1 kappa light chain antibody raised against amino acids 146-164 of p21 Waf1/Cip1 of human origin, also known as CDKN1A or CIP1, in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). p21 Waf1/Cip1 (SX118) antibody is available in non-conjugated forms as well as conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates. p21 Waf1/Cip1 plays a pivotal role in cell cycle regulation by inhibiting cyclin-dependent kinases (Cdks), thereby preventing the phosphorylation of retinoblastoma protein (Rb) and halting cell cycle progression from the G1 to the S phase. Structurally, p21 consists of distinct domains that facilitate interaction with Cdks and proliferating cell nuclear antigen (PCNA), enabling dual role in cell cycle inhibition and DNA repair. These structural features allow p21 to act as a versatile regulator, linking cell cycle control to the maintenance of genomic stability. Expression of p21 is tightly regulated by tumor suppressor p53 in response to DNA damage and cellular stress, highlighting importance in preventing tumorigenesis. Evolutionary conservation of p21, with mouse homolog known as CAP20, underscores fundamental role in cellular homeostasis. anti-p21 Waf1/Cip1 antibody (SX118) is an essential tool for studying structural and functional dynamics of this critical cell cycle regulator.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Waf1/Cip1/CDKN1A p21 Antibody (SX118) has 80 citations in a variety of scientific publications.

Primary antibodies like Anti-Waf1/Cip1/CDKN1A p21 Antibody (SX118) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Waf1/Cip1/CDKN1A p21 Antibody (SX118) Specifications

Alternate Product Name: p21 Waf1/Cip1

Product Clone Name: SX118

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 146-164

Epitope Target: p21 Waf1/Cip1

Epitope Species: human

Product Reactivity/Detection: p21 Waf1/Cip1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 80 citations in various scientific publications

Available Conjugates/Forms for Waf1/Cip1/CDKN1A p21 Antibody (SX118): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Waf1/Cip1/CDKN1A p21 antibody is Waf1/Cip1/CDKN1A p21 Antibody (F-5): sc-6246.