p21 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sterigmatocystin | 10048-13-2 | sc-222329 sc-222329A | 1 mg 5 mg | $74.00 $263.00 | 1 | |
Sterigmatocystin is a notable p21 modulator that interacts intricately with cellular pathways, influencing the regulation of cell cycle checkpoints. Its unique structural attributes facilitate specific binding to regulatory proteins, altering their activity and stability. The compound exhibits distinctive reaction kinetics, characterized by a slow release mechanism that prolongs its effects on target interactions. Additionally, its hydrophobic characteristics enhance membrane permeability, allowing for deeper cellular penetration and modulation of signaling cascades. | ||||||
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $315.00 | ||
Also known as palbociclib, PD-0332991 is a selective inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6). By inhibiting CDK4/6, it indirectly suppresses p21 expression and promotes cell cycle progression. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD-98059 is a selective inhibitor of the mitogen-activated protein kinase kinase (MEK). It indirectly affects p21 expression by interfering with downstream signaling pathways involved in p21 regulation. | ||||||
Abemaciclib | 1231929-97-7 | sc-507342 | 10 mg | $110.00 | ||
LY2835219, or abemaciclib, is another CDK4/6 inhibitor that prevents phosphorylation of the retinoblastoma protein (pRb). This inhibition leads to the downregulation of p21 expression, promoting cell cycle progression. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
Roscovitine is a broad-spectrum CDK inhibitor that targets multiple CDKs, including CDK2, CDK7, and CDKBy inhibiting CDK2, it reduces p21 phosphorylation and stabilizes its expression, causing cell cycle arrest. | ||||||
Indirubin-3′-monoxime | 160807-49-8 | sc-202660 sc-202660A sc-202660B | 1 mg 5 mg 50 mg | $77.00 $315.00 $658.00 | 1 | |
Indirubin-3'-monoxime is a small molecule inhibitor that targets CDKs, including CDK1, CDK2, CDK4, and CDKIts inhibition of CDK2 reduces p21 phosphorylation and increases p21 expression, causing cell cycle arrest. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $254.00 | 41 | |
Flavopiridol is a synthetic flavonoid that inhibits multiple CDKs, including CDK1, CDK2, CDK4, CDK6, and CDKIt affects p21 expression by modulating CDK activity, leading to cell cycle arrest. | ||||||
Olomoucine | 101622-51-9 | sc-3509 sc-3509A | 5 mg 25 mg | $72.00 $274.00 | 12 | |
Olomoucine is a purine derivative that inhibits CDK2, CDK5, and CDKIts inhibition of CDK2 results in the stabilization of p21 expression and subsequent cell cycle arrest. | ||||||
NSC 625987 | 141992-47-4 | sc-203653 | 10 mg | $159.00 | ||
NSC 625987 is a small molecule compound that targets CDK2 and CDKIts inhibition of CDK2 upregulates p21 expression and induces cell cycle arrest. | ||||||
SNS-032 | 345627-80-7 | sc-364621 sc-364621A | 5 mg 10 mg | $169.00 $262.00 | ||
SNS-032 is a selective inhibitor of CDK9, which is involved in the regulation of transcription. By inhibiting CDK9, it indirectly affects p21 expression and modulates the cell cycle. | ||||||