Waf1/Cip1/CDKN1A p21 Antibody (187): sc-817

p21 Waf1/Cip1 Antibody (187) is a mouse monoclonal IgG1 kappa light chain antibody that detects full length p21 Waf1/Cip1 of human origin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry (IHC), and enzyme-linked immunosorbent assay (ELISA). p21 Waf1/Cip1 monoclonal antibody (187) is offered in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase, phycoerythrin, fluorescein isothiocyanate, and multiple Alexa Fluor® conjugates. p21 Waf1/Cip1 plays a crucial role in cell cycle regulation by acting as a potent inhibitor of cyclin-dependent kinases (Cdks), which are essential for the transition between different phases of the cell cycle. By binding tightly to Cdks, p21 Waf1/Cip1 prevents the phosphorylation of retinoblastoma protein (Rb) by various cyclin-Cdk complexes, thereby halting cell cycle progression and promoting cellular senescence. Expression of p21 Waf1/Cip1 is induced by wild-type p53, linking p21 Waf1/Cip1 to the cellular response to DNA damage and stress, which is vital for maintaining genomic stability. p21 Waf1/Cip1 monoclonal antibody (187) serves as a valuable tool for researchers studying cell cycle regulation, DNA damage response, and the molecular mechanisms underlying cellular senescence.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Waf1/Cip1/CDKN1A p21 Antibody (187) has 413 citations in a variety of scientific publications.

Primary antibodies like Anti-Waf1/Cip1/CDKN1A p21 Antibody (187) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Waf1/Cip1/CDKN1A p21 Antibody (187) Specifications

Alternate Product Name: p21 Waf1/Cip1

Product Clone Name: 187

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: p21 Waf1/Cip1

Epitope Species: human

Product Reactivity/Detection: p21 Waf1/Cip1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 413 citations in various scientific publications

Available Conjugates/Forms for Waf1/Cip1/CDKN1A p21 Antibody (187): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent

The preferred Waf1/Cip1/CDKN1A p21 antibody is Waf1/Cip1/CDKN1A p21 Antibody (F-5): sc-6246.