CDKN2C/p18 INK4c Antibody (H-7): sc-514580

p18 INK4C Antibody (H-7) is a mouse monoclonal IgG2a antibody that detects p18 INK4C in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). p18 INK4C plays a crucial role in regulating the cell cycle by specifically inhibiting cyclin D-Cdk6 kinase activity, which is essential for preventing uncontrolled cell proliferation—a hallmark of cancer. p18 INK4C is primarily located in the nucleus, where p18 INK4C interacts with cyclin-dependent kinases (Cdks) to modulate their activity, thereby influencing cell cycle progression. p18 INK4C′s nuclear localization enables effective regulation of the cell cycle at critical checkpoints, ensuring that cells do not proceed to division when conditions are unfavorable. Additionally, p18 INK4C has been shown to interact strongly with Cdk6 and to a lesser extent with Cdk4, forming binary complexes that are vital for function, unlike other cyclin-dependent kinase inhibitors that form ternary complexes. The gene encoding p18 INK4C is located adjacent to the p16 INK4A gene on chromosome 9p21.3, a region frequently associated with chromosomal abnormalities in various human tumors, highlighting p18 INK4C′s potential role as a tumor suppressor. Anti-p18 INK4C antibody (H-7) is an invaluable tool for researchers studying cell cycle regulation and its implications in cancer biology.

The preferred CDKN2C/p18 INK4c antibody is CDKN2C/p18 INK4c Antibody (118.2): sc-9965.