CDKN2C/p18 INK4c Antibody (B-2): sc-514704

p18 INK4C Antibody (B-2) is a mouse monoclonal IgG2b antibody that detects p18 INK4C in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). p18 INK4C plays a crucial role in regulating the cell cycle by specifically inhibiting cyclin D-Cdk6 kinase activity, which is essential for preventing uncontrolled cell proliferation—a hallmark of cancer. p18 INK4C is primarily located in the nucleus, where p18 INK4C interacts with cyclin-dependent kinases, thereby modulating their activity and ensuring proper cell cycle progression. The gene encoding p18 INK4C is closely related to the p16 INK4A gene, both of which are located on chromosome 9p21.3, a region frequently associated with chromosomal abnormalities in various human tumors. The ability of p18 INK4C to form binary complexes with Cdk6, while lacking significant interaction with other cyclin-dependent kinases, highlights p18 INK4C′s specificity and importance in the regulation of cell cycle checkpoints. Anti-p18 INK4C antibody (B-2) enables researchers to gain valuable insights into the mechanisms of cell cycle regulation and the potential implications of its dysregulation in cancer biology.

The preferred CDKN2C/p18 INK4c antibody is CDKN2C/p18 INK4c Antibody (118.2): sc-9965.