p130 Cas Antibody (C-2): sc-515479
- p130 Cas Antibody (C-2) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 8-28 near the N-terminus of p130 Cas of rat origin
- recommended for detection of p130 Cas of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for p130 Cas Antibody (C-2) for WB applications. These reagents are now offered in bundles with p130 Cas Antibody (C-2) (see ordering information below).
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p130 Cas Antibody (C-2) is a mouse monoclonal IgG1 antibody that detects p130 Cas in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). p130 Cas, also known as breast cancer anti-estrogen resistance protein 1 or Cas scaffolding protein family member 1, plays a crucial role in cellular signaling pathways, particularly in cancer progression and metastasis. p130 Cas is primarily located in the cytoplasm and is involved in the regulation of cell adhesion and migration, which are essential processes for tissue development and repair, as well as for the invasive behavior of cancer cells. Multiple SH2-binding motifs within p130 Cas enable interactions with various signaling molecules, facilitating signal transmission from the cell surface to the nucleus. p130 Cas undergoes significant post-translational modifications, including tyrosine phosphorylation, which enhances protein interactions and modulates signaling pathways. The identification of p130 Cas and related proteins, such as Sin and Cas-L, underscores p130 Cas importance in oncogenic signaling and highlights p130 Cas potential as a therapeutic target in cancer treatment.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p130 Cas Antibody (C-2) | sc-515479 | 200 µg/ml | $316.00 | |||
p130 Cas Antibody (C-2): m-IgG Fc BP-HRP Bundle | sc-541058 | 200 µg Ab; 10 µg BP | $354.00 | |||
p130 Cas Antibody (C-2): m-IgG1 BP-HRP Bundle | sc-542555 | 200 µg Ab; 20 µg BP | $354.00 | |||
p130 Cas (C-2) Neutralizing Peptide | sc-515479 P | 100 µg/0.5 ml | $68.00 |