p130 Cas Antibody (3F309): sc-71796
- p130 Cas Antibody (3F309) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against recombinant p130 Cas of human origin
- recommended for detection of p130 Cas of mouse, rat and human origin by WB, IP, IF and IHC(P)
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for p130 Cas Antibody (3F309) for WB and IHC(P) applications. This reagent is now offered in a bundle with p130 Cas Antibody (3F309) (see ordering information below).
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p130 Cas Antibody (3F309) is a mouse monoclonal IgG1 antibody that detects p130 Cas in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. p130 Cas, also known as Crk-associated substrate, plays a crucial role in cellular signaling pathways, particularly in cell adhesion and migration. p130 Cas is primarily located in the cytoplasm but can translocate to the cell membrane upon tyrosine phosphorylation, which is essential for mediating signals from growth factor receptors and integrins. This relocation allows for dynamic regulation of signaling pathways that control cell behavior, including proliferation and differentiation. p130 Cas contains multiple SH2-binding motifs, making p130 Cas a key substrate for various protein tyrosine kinases, including v-Src and v-Crk, which influence oncogenic signaling. Anti-p130 Cas antibody (3F309) enables researchers to effectively study the phosphorylation status and localization of p130 Cas, providing insights into cancer biology and other diseases.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p130 Cas Antibody (3F309) | sc-71796 | 200 µg/ml | $316.00 | |||
p130 Cas Antibody (3F309): m-IgG Fc BP-HRP Bundle | sc-539406 | 200 µg Ab; 10 µg BP | $354.00 |