p130 Antibody (DCS-211): sc-56176
- p130 Antibody (DCS-211) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 878-913 of p130 of human origin
- recommended for detection of p130 of mouse, rat and human origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for p130 Antibody (DCS-211). This work is in progress.
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p130 Antibody (DCS-211) is a mouse monoclonal IgG1 antibody that detects p130 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). p130, a member of the retinoblastoma (Rb) protein family, plays a crucial role in regulating the cell cycle and maintaining cellular quiescence. p130 is primarily located in the nucleus, where p130 interacts with E2F transcription factors to inhibit cell cycle progression, thereby preventing uncontrolled cell proliferation, which is vital for tumor suppression. Notably, p130 undergoes specific post-translational modifications, including phosphorylation on serine and threonine residues, particularly during the G0 phase and early G1 phase of the cell cycle. These modifications are essential for p130 function, as modifications regulate p130 activity and stability, allowing p130 to respond to cellular signals that dictate whether a cell should enter the cell cycle or remain in a quiescent state. The unique phosphorylation pattern of p130, especially within a region known as the Loop, highlights p130′s distinct regulatory mechanisms compared to other Rb family members, such as pRb and p107. p130 (DCS-211) antibody is an invaluable tool for researchers studying cell cycle regulation and the molecular mechanisms underlying cancer development.
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p130 Antibody (DCS-211) References:
- Regulation of cellular senescence by Rb2/p130. | Helmbold, H., et al. 2006. Oncogene. 25: 5257-62. PMID: 16936745
- Rb2/p130 and protein phosphatase 2A: key mediators of ovarian carcinoma cell growth suppression by all-trans retinoic acid. | Soprano, KJ., et al. 2006. Oncogene. 25: 5315-25. PMID: 16936753
- p130 Crk-associated substrate (CAS) in vascular smooth muscle. | Tang, DD. 2009. J Cardiovasc Pharmacol Ther. 14: 89-98. PMID: 19329671
- The switch from pRb/p105 to Rb2/p130 in DNA damage and cellular senescence. | Helmbold, H., et al. 2012. J Cell Physiol. 227: 508-13. PMID: 21465484
- pRb2/p130 localizes to the cytoplasm in diffuse gastric cancer. | Cito, L., et al. 2015. J Cell Physiol. 230: 802-5. PMID: 25205458
- RB, p130 and p107 differentially repress G1/S and G2/M genes after p53 activation. | Schade, AE., et al. 2019. Nucleic Acids Res. 47: 11197-11208. PMID: 31667499
- Angiomotin-p130 inhibits vasculogenic mimicry formation of small cell lung cancer independently of Smad2/3 signal pathway. | Li, D., et al. 2021. J Bioenerg Biomembr. 53: 295-305. PMID: 33712992
- Fragment-based exploration of the 14-3-3/Amot-p130 interface. | Centorrino, F., et al. 2022. Curr Res Struct Biol. 4: 21-28. PMID: 35036934
- The E2F4/p130 Repressor Complex Cooperates with Oncogenic ΔNp73α To Inhibit Gene Expression in Human Papillomavirus 38 E6/E7-Transformed Keratinocytes and in Cancer Cells. | Taverniti, V., et al. 2023. mSphere. 8: e0005623. PMID: 36883841
- Viral oncoprotein binding to pRB, p107, p130, and p300. | Ludlow, JW. and Skuse, GR. 1995. Virus Res. 35: 113-21. PMID: 7762286
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p130 Antibody (DCS-211) | sc-56176 | 200 µg/ml | $322.00 |