p-VASP Antibody (A-7): sc-365563

p-VASP Antibody (A-7) is a mouse monoclonal IgG2b antibody that detects VASP in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-VASP antibody (A-7) specifically recognizes the phosphorylated form of VASP, a proline-rich protein that plays a crucial role in the regulation of actin dynamics and cellular architecture. VASP is primarily located in focal adhesions and microfilaments, where VASP interacts with actin filaments to facilitate cell motility and shape changes, making VASP essential for processes such as wound healing and immune responses. The proper localization and function of VASP are vital, as dysregulation can lead to impaired cellular functions and contribute to various diseases, including cancer and cardiovascular disorders. VASP undergoes post-translational modifications, including phosphorylation at serine residues, which modulate VASP activity and interactions with other proteins, further underscoring VASP importance in cellular signaling pathways. VASP monoclonal antibody (A-7) provides insights into the dynamic processes of cell movement and structure, serving as an invaluable tool for researchers studying the intricate mechanisms of cell biology.

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p-VASP Antibody (A-7) References:

1. Age-related decrease of protein kinase G activation in vascular smooth muscle cells.  |  Lin, CS., et al. 2001. Biochem Biophys Res Commun. 287: 244-8. PMID: 11549281
2. The 46/50 kDa phosphoprotein VASP purified from human platelets is a novel protein associated with actin filaments and focal contacts.  |  Reinhard, M., et al. 1992. EMBO J. 11: 2063-70. PMID: 1318192
3. An siRNA screen identifies RSK1 as a key modulator of lung cancer metastasis.  |  Lara, R., et al. 2011. Oncogene. 30: 3513-21. PMID: 21423205
4. Staphylococcus aureus lipoteichoic acid inhibits platelet activation and thrombus formation via the Paf receptor.  |  Waller, AK., et al. 2013. J Infect Dis. 208: 2046-57. PMID: 23911710
5. Anti-peroxynitrite treatment ameliorated vasorelaxation of resistance arteries in aging rats: involvement with NO-sGC-cGKs pathway.  |  Ma, L., et al. 2014. PLoS One. 9: e104788. PMID: 25117910
6. Identification, purification, and characterization of a zyxin-related protein that binds the focal adhesion and microfilament protein VASP (vasodilator-stimulated phosphoprotein).  |  Reinhard, M., et al. 1995. Proc Natl Acad Sci U S A. 92: 7956-60. PMID: 7644520
7. cAMP- and cGMP-dependent protein kinase phosphorylation sites of the focal adhesion vasodilator-stimulated phosphoprotein (VASP) in vitro and in intact human platelets.  |  Butt, E., et al. 1994. J Biol Chem. 269: 14509-17. PMID: 8182057
8. Defects in Wiskott-Aldrich syndrome blood cells.  |  Remold-O'Donnell, E., et al. 1996. Blood. 87: 2621-31. PMID: 8639877
9. Studies of the expression of the Wiskott-Aldrich syndrome protein.  |  Stewart, DM., et al. 1996. J Clin Invest. 97: 2627-34. PMID: 8647957
10. Wiskott-Aldrich syndrome: no strict genotype-phenotype correlations but clustering of missense mutations in the amino-terminal part of the WASP gene product.  |  Schindelhauer, D., et al. 1996. Hum Genet. 98: 68-76. PMID: 8682510

The preferred VASP antibody is VASP Antibody (A-11): sc-46668.