p-Stat6 Antibody (pY641.18): sc-136019

p-Stat6 Antibody (pY641.18) is a mouse monoclonal IgG2a kappa light chain antibody that detects Tyr 641 phosphorylated Stat6 of human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). anti-p-Stat6 antibody (pY641.18) is available in a non-conjugated form, allowing for versatile applications in various experimental setups. Stat6 plays a crucial role in mediating the effects of cytokines, particularly interleukin-4 (IL-4), which is vital for immune responses and gene expression regulation. Upon IL-4 stimulation, Stat6 undergoes phosphorylation at specific tyrosine and serine residues, leading to dimerization and subsequent nuclear translocation. This process enables Stat6 to function as a sequence-specific transcription factor, binding to target gene promoters and activating transcription. Stat6′s ability to regulate genes involved in immune responses highlights significance in both normal physiology and pathological conditions, such as allergies and asthma. Additionally, Stat6 undergoes phosphorylation in response to interleukin-15 (IL-15), further underscoring involvement in various signaling pathways. Activation of Stat6 by Janus kinase family protein tyrosine kinases is critical for full cellular response to IL-4, making p-Stat6 (pY641.18) monoclonal antibody an invaluable tool for researchers studying these signaling mechanisms and implications in health and disease.

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p-Stat6 Antibody (pY641.18) References:

1. The Jak-STAT pathway: cytokine signalling from the receptor to the nucleus.  |  Heim, MH. 1999. J Recept Signal Transduct Res. 19: 75-120. PMID: 10071751
2. Interleukin-4-induced transcriptional activation by stat6 involves multiple serine/threonine kinase pathways and serine phosphorylation of stat6.  |  Pesu, M., et al. 2000. Blood. 95: 494-502. PMID: 10627454
3. Interleukin-15 induces rapid tyrosine phosphorylation of STAT6 and the expression of interleukin-4 in mouse mast cells.  |  Masuda, A., et al. 2000. J Biol Chem. 275: 29331-7. PMID: 10882748
4. Shift from pStat6 to pStat3 predominance is associated with inflammatory bowel disease-associated dysplasia.  |  Wick, EC., et al. 2012. Inflamm Bowel Dis. 18: 1267-74. PMID: 22021169
5. IFI35 Promotes Renal Cancer Progression by Inhibiting pSTAT1/pSTAT6-Dependent Autophagy.  |  Chai, D., et al. 2022. Cancers (Basel). 14: PMID: 35740527
6. Transcriptional responses to polypeptide ligands: the JAK-STAT pathway.  |  Schindler, C. and Darnell, JE. 1995. Annu Rev Biochem. 64: 621-51. PMID: 7574495
7. An interleukin-4-induced transcription factor: IL-4 Stat.  |  Hou, J., et al. 1994. Science. 265: 1701-6. PMID: 8085155
8. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins.  |  Darnell, JE., et al. 1994. Science. 264: 1415-21. PMID: 8197455
9. Activation of STAT6 is not dependent on phosphotyrosine-mediated docking to the interleukin-4 receptor and can be blocked by dominant-negative mutants of both receptor subunits.  |  Moriggl, R., et al. 1998. Eur J Biochem. 251: 25-35. PMID: 9492265
10. A conditionally active form of STAT6 can mimic certain effects of IL-4.  |  Kamogawa, Y., et al. 1998. J Immunol. 161: 1074-7. PMID: 9686563

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-p-Stat6 Antibody (pY641.18) has 18 citations in a variety of scientific publications.

Primary antibodies like Anti-p-Stat6 Antibody (pY641.18) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

p-Stat6 Antibody (pY641.18) Specifications

Alternate Product Name: p-Stat6

Product Clone Name: pY641.18

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: Tyr 641

Epitope Target: Stat6

Epitope Species: human

Product Reactivity/Detection: Tyr 641 phosphorylated Stat6

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 18 citations in various scientific publications

Available Conjugates/Forms for p-Stat6 Antibody (pY641.18): N/A