p-Stat3 Antibody (9E12): sc-81523

p-Stat3 Antibody (9E12) is a mouse monoclonal IgG1 antibody that detects Tyr 705 phosphorylated Stat3 in mouse, rat, human, and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). p-Stat3 monoclonal antibody (9E12) is available in a non-conjugated form, allowing for versatile experimental setups. Stat3 plays a crucial role in mediating cellular responses to various extracellular signals, particularly in the context of growth factors and cytokines. Upon activation, Stat3 translocates to the nucleus where it regulates the expression of genes involved in cell proliferation, survival, and differentiation, making it a key player in processes such as immune response and oncogenesis. Notably, Stat3 is subject to various post-translational modifications, including phosphorylation at Tyr 705, which is essential for activation and subsequent transcriptional activity. This modification not only enhances Stat3′s ability to dimerize and bind to DNA but also influences interaction with other proteins, thereby modulating function in signaling pathways. Understanding the dynamics of Stat3 activation and regulatory mechanisms is vital for elucidating its role in diseases, particularly cancer, where aberrant Stat3 signaling is often implicated. p-Stat3 (9E12) antibody provides a reliable tool for investigating the phosphorylation-dependent activation of Stat3 and its pivotal role in regulating cellular processes and disease progression.

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p-Stat3 Antibody (9E12) References:

1. STAT3, p-STAT3 and HIF-1α are associated with vasculogenic mimicry and impact on survival in gastric adenocarcinoma.  |  Song, YY., et al. 2014. Oncol Lett. 8: 431-437. PMID: 24959290
2. Inflammatory factor TNF-α promotes the growth of breast cancer via the positive feedback loop of TNFR1/NF-κB (and/or p38)/p-STAT3/HBXIP/TNFR1.  |  Cai, X., et al. 2017. Oncotarget. 8: 58338-58352. PMID: 28938560
3. STAT3-siRNA induced B16.F10 melanoma cell death: more association with VEGF downregulation than p-STAT3 knockdown.  |  Alshamsan, A. 2018. Saudi Pharm J. 26: 1083-1088. PMID: 30532628
4. miR-22-3p enhances the intrinsic regenerative abilities of primary sensory neurons via the CBL/p-EGFR/p-STAT3/GAP43/p-GAP43 axis.  |  Li, B., et al. 2020. J Cell Physiol. 235: 4605-4617. PMID: 31663116
5. The role of p-Stat3 Y705 immunohistochemistry in glioblastoma prognosis.  |  Susman, S., et al. 2019. Diagn Pathol. 14: 124. PMID: 31690341
6. P-STAT3 Inhibition Activates Endoplasmic Reticulum Stress-Induced Splenocyte Apoptosis in Chronic Stress.  |  Song, M., et al. 2020. Front Physiol. 11: 680. PMID: 32714202
7. CCL5 Suppresses Klotho Expression via p-STAT3/DNA Methyltransferase1-Mediated Promoter Hypermethylation.  |  Liu, Q., et al. 2022. Front Physiol. 13: 856088. PMID: 35299661
8. Nuclear Expression of p-STAT3 Is Associated with Poor Prognosis in ER(-) Breast Cancer.  |  Nakagawa, T., et al. 2022. Clin Pract. 12: 157-167. PMID: 35314590
9. Expression of p-STAT3 and c-Myc correlates with P2-HNF4α expression in nonalcoholic fatty liver disease (NAFLD).  |  Younes, M., et al. 2022. Oncotarget. 13: 1308-1313. PMID: 36473131
10. p-STAT3-elevated E3 ubiquitin ligase DTX4 confers the stability of HBV cccDNA by ubiquitinating APOBEC3B in liver.  |  Zhao, L., et al. 2024. Theranostics. 14: 6036-6052. PMID: 39346550

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-p-Stat3 Antibody (9E12) has 29 citations in a variety of scientific publications.

Primary antibodies like Anti-p-Stat3 Antibody (9E12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

p-Stat3 Antibody (9E12) Specifications

Alternate Product Name: Stat3

Product Clone Name: 9E12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids: Tyr 705

Epitope Target: Stat3

Epitope Species: human

Product Reactivity/Detection: Tyr 705 phosphorylated Stat3

Species Reactivity/Detection: mouse, rat, human, canine

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 50 µg IgG₁ in 0.5 ml of PBS with < 0.1% sodium azide, 0.1% gelatin, PEG and sucrose

Research Citations: 29 citations in various scientific publications

Available Conjugates/Forms for p-Stat3 Antibody (9E12): N/A

The preferred p-Stat3 antibody is p-Stat3 Antibody (B-7): sc-8059.