p-Rb Antibody (F-2): sc-377539

p-Rb Antibody (F-2) is a mouse monoclonal IgG1 antibody that detects retinoblastoma protein (Rb) in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). anti-Rb antibody (F-2) specifically recognizes the phosphorylated form of Rb, which plays a crucial role in regulating the cell cycle and maintaining cellular homeostasis. Rb protein is primarily located in the nucleus, where Rb functions as a key tumor suppressor by controlling the transition from G1 phase to S phase of the cell cycle. This nuclear localization allows Rb to interact with transcription factors and other regulatory proteins that govern cell proliferation and differentiation. When phosphorylated, Rb releases its hold on these transcription factors, thereby promoting cell cycle progression. Dysregulation of Rb, often due to mutations or aberrant phosphorylation, can lead to uncontrolled cell division and contribute to the development of various cancers, including retinoblastoma. The ability of anti-Rb antibody (F-2) to detect Rb in its phosphorylated state makes anti-Rb antibody (F-2) an invaluable tool for researchers studying cell cycle regulation and cancer biology.

The preferred Rb antibody is Rb Antibody (IF8): sc-102.