p-phospholemman Antibody (Ser 68): sc-517349
- p-phospholemman Antibody (Ser 68) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against a recombinant protein corresponding to the Ser 68 phosphorylated region of phospholemman of mouse origin
- recommended for detection of Ser 68 phosphorylated phospholemman of mouse and rat origin by WB
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for p-phospholemman Antibody (Ser 68). This work is in progress.
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p-phospholemman Antibody (Ser 68) is a mouse monoclonal IgG1 antibody that detects phospholemman in mouse and rat samples through western blotting (WB). Anti-phospholemman antibody (Ser 68) specifically recognizes the phosphorylated form of phospholemman at serine 68, a critical site that plays a significant role in phospholemman function. Phospholemman, a member of the FXYD family of small membrane proteins, is primarily located in the plasma membrane of cardiac and skeletal muscle cells, where phospholemman is involved in the regulation of ion channels. This localization is crucial as phospholemman modulates the activity of Na, K-ATPase, thereby influencing muscle contractility and cellular excitability. The phosphorylation of phospholemman in response to adrenergic or insulin stimulation highlights phospholemman′s importance in muscle physiology, particularly in the context of cardiac function and response to metabolic signals. Anti-phospholemman antibody (Ser 68) enables researchers to gain insights into the regulatory mechanisms of muscle contraction and the physiological roles of phospholemman in health and disease.
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p-phospholemman Antibody (Ser 68) References:
- Ion currents through mutant phospholemman channel molecules. | Chen, ZH., et al. 1999. Recept Channels. 6: 435-47. PMID: 10635061
- Volume sensitive efflux of taurine in HEK293 cells overexpressing phospholemman. | Morales-Mulia, M., et al. 2000. Biochim Biophys Acta. 1496: 252-60. PMID: 10771093
- Gene structure and expression of phospholemman in mouse. | Bogaev, RC., et al. 2001. Gene. 271: 69-79. PMID: 11410367
- Phospholemman (FXYD1) associates with Na,K-ATPase and regulates its transport properties. | Crambert, G., et al. 2002. Proc Natl Acad Sci U S A. 99: 11476-81. PMID: 12169672
- Phospholemman phosphorylation alters its fluorescence resonance energy transfer with the Na/K-ATPase pump. | Bossuyt, J., et al. 2006. J Biol Chem. 281: 32765-73. PMID: 16943195
- Regulation of cardiac Na+/Ca2+ exchanger by phospholemman. | Cheung, JY., et al. 2007. Ann N Y Acad Sci. 1099: 119-34. PMID: 17446450
- Phospholemman: its role in normal cardiac physiology and potential as a druggable target in disease. | Shattock, MJ. 2009. Curr Opin Pharmacol. 9: 160-6. PMID: 19195931
- The inhibitory effect of phospholemman on the sodium pump requires its palmitoylation. | Tulloch, LB., et al. 2011. J Biol Chem. 286: 36020-36031. PMID: 21868384
- Discovery and Characterization of the Phospholemman/SIMP/Viroporin Superfamily. | Tyler, D., et al. 2022. Microb Physiol. 32: 83-94. PMID: 35152214
- Glutathione-dependent depalmitoylation of phospholemman by peroxiredoxin 6. | Howie, J., et al. 2024. Cell Rep. 43: 113679. PMID: 38236777
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p-phospholemman Antibody (Ser 68) | sc-517349 | 100 µg/ml | $316.00 |