The chemical class referred to as Phospholemman Inhibitors encompasses a diverse range of molecules and compounds that have been developed and studied for their ability to modulate the activity of phospholemman, a regulatory protein predominantly found in cardiac and skeletal muscle cells. Phospholemman plays a critical role in regulating ion transport, particularly through its interaction with the sodium-potassium pump (Na+/K+-ATPase), which is vital for maintaining proper ion homeostasis in these cells. Phospholemman Inhibitors are specifically designed to interact with phospholemman or related pathways, potentially altering its influence on ion transport processes. By targeting phospholemman, these inhibitors offer a means to investigate and manipulate the intricate mechanisms underlying ion regulation in various physiological contexts.
The exploration of Phospholemman Inhibitors contributes to advancing our understanding of cellular ion dynamics and the intricate interplay of regulatory proteins in modulating essential cellular functions. Ongoing research endeavors continue to elucidate the mechanisms of action and broader implications associated with Phospholemman Inhibitors, further enhancing our knowledge of cellular processes at the molecular level.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
While primarily known as a diabetes agent in research, rosiglitazone has been found to modulate sodium transport in the heart, possibly affecting phospholemman-mediated regulation. | ||||||
12β-Hydroxydigitoxin | 20830-75-5 | sc-213604 sc-213604A | 1 g 5 g | $143.00 $694.00 | ||
Another cardiac glycoside, 12β-Hydroxydigitoxin affects ion transport and could indirectly modulate the role of phospholemman in regulating sodium-potassium pumps. | ||||||
Captopril | 62571-86-2 | sc-200566 sc-200566A | 1 g 5 g | $49.00 $91.00 | 21 | |
An angiotensin-converting enzyme (ACE) inhibitor used for hypertension, captopril may have downstream effects on ion transport and phospholemman function. | ||||||
Carvedilol | 72956-09-3 | sc-200157 sc-200157A sc-200157B sc-200157C sc-200157D | 100 mg 1 g 10 g 25 g 100 g | $124.00 $240.00 $530.00 $999.00 $1530.00 | 2 | |
This non-selective beta-blocker with alpha-blocking properties could influence cardiac ion transport pathways, including those regulated by phospholemman. | ||||||